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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit February 24, 2016

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Fernanda Ricci Wins 2016 JALA & JBS Art of Science Contest
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Congratulations to Fernanda Ricci of IIT@SEMM in Italy, top vote-getter and winner of a $500 Amazon gift card for her beautiful image — a mosaic representation of cell colonies and the resulting automated segmentation obtained with Colony Assay Toolbox (CaT, F. Ricci et al. JBS 2014).

The illustrations are representative of a colony formation in a 384 multi-well format; the single wells are entirely acquired by using a 4x objective combined with a large camera in wide-field microscopy (Nikon Ti-Eclipse). All 10 finalists receive 60 days free online access to the SAGE Pharmacology & Biomedical Collection (100,000+ research reports!).
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SLAS ELN Reports: Exploring the Potential of Mass Spectrometry in Drug Discovery — A JBS Special Issue
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There's an element of mystery and a few myths around mass spectrometry (MS) that JBS Guest Editors Jonathan Wingfield, Ph.D., AstraZeneca (U.K.), and Ian Wilson, D.Sc., of Imperial College (U.K.), hope to dispel.

"One is the idea that MS is a high-tech platform that tends to be operated by specialists," comments Wingfield. "That impression can be a potential barrier that stops people from wanting to use this type of technology. I hope this collection of papers appearing in a rigorously peer-reviewed, mainstream scientific journal will debunk some of these myths and get people interested in the potential of MS."

Read more in the latest feature article in the SLAS Electronic Laboratory Neighborhood e-zine.
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FREE Access to 'Novel Acoustic Loading of a Mass Spectrometer' Presentation and JALA Special Issue on Advancing Scientific Innovation with ADE
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The 2015 SLAS Innovation Award-winning presentation by Jonathan Wingfield on "Novel Acoustic Loading of a Mass Spectrometer — Towards Next Generation High-Throughput MS Screening" can now be accessed for free courtesy of sponsorship by Labcyte Inc.

Plus, more than 200 pages of peer-reviewed scientific reports on acoustic droplet ejection (ADE) are available for FREE at JALA Online, also courtesy of Labcyte.
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SLAS Webinar: The SmartLab of the Future
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On March 24, Felix Lenk, Ph.D., Technische Universität Dresden, presents "The SmartLab of the Future: Benchtop Lab Automation with the PetriJet and NutriJet Platforms." Lenk describes the PetriJet platform, which provides a lab with a compact device for the automated handling of culture dishes in batches of 20 or continuously.

Together with exchangeable processing stations, nearly all tasks associated with culture dishes like identification, filling and imaging can be effectively automated. NutriJet provides a lab with a fully automated solution for medium composition right from the container of the ingredient manufacturer and is fully GMP compliant. The March 24 Webinar, presented by JALA and JBS, the official journals of SLAS, is free to SLAS dues-paying members.
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FREE at JALA Online: Miniaturization Technologies for Efficient Single-Cell Library Preparation for Next-Generation Sequencing
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A collaborative team from University of California, San Diego and TTP Labtech share results that "indicate that the application of a nanoliter-scale liquid handling system enables automated library preparation for single-cell transcriptome sequencing at markedly lower reaction volume without compromising reproducibility, quality, or complexity of the resulting libraries.

"This technical advance will significantly decrease both the cost and labor required for these studies, making analysis of hundreds to thousands of single cells feasible. The ability to carry out large-scale studies will allow for detailed studies aimed at detecting transcriptional differences between cell populations collected at multiple time points or exposed to different experimental conditions, as well as identifying rare subpopulations of cells."
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FREE to All at SLAS.org: 'Analyzing the Complexity of Drug Resistance in Cancer' by Michael M. Gottesman
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Recorded live at SLAS2016 and now freely accessible to all, this keynote presentation by Michael Gottesman, Ph.D., chief of the U.S. National Cancer Institute's Laboratory of Cell Biology, discusses the daunting complexity of resistance mechanisms in cancer cells, the Institute's approach to cell-based research and recent discoveries related to oncology. More



New at SLAS.org: HT-MALDI-MS as a Complete Label-Free Drug Discovery Platform — From Target Characterization through HTS to Hit Follow-Up
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From the SLAS2016 Bioanalytics, Biomarkers and Diagnostics track, this recorded presentation by Scott Busby, Novartis Institutes for Biomedical Research, USA, explores the HT-MALDI-MS platform, which overcomes many previous limitations of mass spectrometry-based screening assays.

This includes superior throughput to LCMS and SPE coupled ESI assays in both assay development and screening times, significantly reducing assay costs by eliminating expensive solvents and antibody reagents used in other techniques and enabling new assays that are not possible with conventional TR-FRET assays. It is one of seven presentations recorded at SLAS2016 for free on-demand viewing by SLAS dues-paid members and full conference participants.
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Scientists Find Popular Stem Cell Techniques Safe
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A new study led by scientists at The Scripps Research Institute and the J. Craig Venter Institute shows that the act of creating pluripotent stem cells for clinical use is unlikely to pass on cancer-causing mutations to patients. The research, published in the journal Nature Communications, is an important step in assessing patient safety in the rapidly developing field of stem cell therapies. More


Chemistry Trick Paves Way for Safer Diabetes Medication
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Knud J. Jensen is a professor at the University of Copenhagen's Department of Chemistry. Together with Technical University of Denmark and Novo Nordisk researchers, he has published Construction of Insulin 18-mer Nanoassemblies Driven by Coordination to Iron (II) and Zink (II) Ions at Distinct Sites" in the journal, Angewandte Chemie. "We have discovered an entirely new method of modifying a molecule — Insulin — that is important for 35 million diabetes patients. We are incredibly happy with that," says Professor Jensen. More


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Why Do Our Cell's Power Plants Have Their Own DNA?
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It's one of the big mysteries of cell biology. Why do mitochondria — the oval-shaped structures that power our cells — have their own DNA, and why have they kept it when the cell itself has plenty of its own genetic material? A new study may have found an answer. Scientists think that mitochondria were once independent single-celled organisms until, more than a billion years ago, they were swallowed by larger cells. More


Study Reveals Mechanism Behind Enzyme That Tags Unneeded DNA
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Researchers have discovered the two-step process that activates an essential human enzyme, called Suv39h1, which is responsible for organizing large portions of the DNA found in every living cell. For any particular cell, such as a skin or brain cell, much of this genetic information is extraneous and must be packed away to allow sufficient space and resources for more important genes. Failure to properly pack DNA jeopardizes the stability of chromosomes and can result in severe diseases. More


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Whole-Genome Study Allays Cancer Fears Surrounding Stem Cell Techniques
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Cell-replacement therapies that depend on induced pluripotent stem cells inspire hope and fear — hope that cells derived from iPSCs will actualize regenerative medicine; fear that the very same cells will bring cancer-causing mutations to patients. The fear lingers even though several studies have already suggested that iPSCs can be considered safe. These studies were conducted because iPSCs are created only after they have endured the rigors of reprogramming, stresses thought to be capable of introducing deleterious mutations. More


Protein Structure Illuminates How Viruses Take Over Cells
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Using cutting-edge imaging technology, Salk Institute and Harvard Medical School researchers have determined the structure of a protein complex that lets viruses similar to the human immunodeficiency virus establish permanent infections within their hosts. Contrary to previous assumptions, the newly detailed viral protein complex structure indicates that this type of molecular architecture differs across retroviruses. More


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Same Gene, Different Functions
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The human genome contains roughly 20,000 protein-coding genes, yet the number of proteins in human cells is thought to be more like 100,000. Researchers from three institutions in North America have now shown that at least some of the diversity of proteins' functions in the cell may be due to the widely diverging roles of protein isoforms — structurally similar variants produced as a result of slight differences during the translation of a single gene. More


Enzyme Inhibitors Block Ebola
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The 2014 Ebola epidemic drew the world's attention to the virus, which multiplies rapidly inside human tissues, destroying entire organs within days. Although antibodies have proved helpful in treating Ebola, no drugs block the virus. In many cases, all doctors can do is treat the symptoms and wait for the immune system to work. Now, researchers have engineered a group of small molecules that inhibit key cellular proteins, blocking Ebola's ability to infect mouse cells and offering a new approach for battling the deadly virus. More


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Career


Laboratory Automation Engineer/Associate Scientist or Sr. Engineer/Scientist, Process Development
Genentech
US – CA – South San Francisco

Research Technician
Drexel University College of Medicine Department of Pharmacology
US – PA – Philadelphia

Sr. Scientist II, Cell Based Discovery
The Coca-Cola Company
US – GA – Atlanta

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