ASCLS eNewsBytes
Mar. 6, 2012

NOSH-aspirin: A novel nitric oxide-hydrogen sulfide-releasing hybrid: A new class of anti-inflammatory pharmaceuticals
ACS Medicinal Chemistry Letters
Scientists have combined two new "designer" forms of aspirin into a hybrid substance that appears more effective than either of its forebears in controlling the growth of several forms of cancer in laboratory tests. Their report on the new NOSH-aspirin, so named because it releases nitric oxide and hydrogen sulfide, appears in the journal ACS Medicinal Chemistry Letters.More

New guidelines aim to raise standards for laboratory-acquired infections in clinical pathology laboratories
Dark Daily
Clinical laboratories and pathology groups should be aware of new safety guidelines that address the risk of laboratory-acquired infections. A panel of experts convened by the Centers for Disease Control and Prevention recently released safety guidelines for medical laboratory workers. The guidelines are intended to improve safety specifically in diagnostic laboratories that handle specimens from humans and animals. More

Adapting personal glucose monitors to detect DNA
Analytical Chemistry
An inexpensive device used by millions of people with diabetes could be adapted into a home DNA detector that enables individuals to perform home tests for viruses and bacteria in human body fluids, in food and in other substances, scientists are reporting in a new study. The report on this adaptation of the ubiquitous personal glucose monitor, typically used to test blood sugar levels, appears in ACS' journal Analytical Chemistry.More

3-D ultrasound effective for breast lesion classification
Medscape Medical News
Multimodal tomography, a novel 3-D imaging technology, is effective in detecting and classifying breast lesions as small as 2 mm in size, according to research presented here European Congress of Radiology (ECR) 2012. The unique imaging method, first introduced at ECR 2011, uses transmission ultrasound to perform a 3-D scan of a pendulant breast in a water bath, and reconstructs multiple images for each coronal slice.More

Best jobs in 2012: Clinical laboratory technician
U.S. News & World Report
Hospitals are big places with lots of moving parts working in unison to keep the entire operation humming. Clinical laboratory technicians represent some of the most important pieces of this elaborate framework. Clinical laboratory technicians are responsible for a number of tasks, including examining body fluids and cells and matching blood for transfusions. With steady population growth and the development of new lab tests, the job market for clinical laboratory technicians is expected to remain strong.More

Universal lipid screening in children
Clinical Laboratory News
A wealth of evidence has substantiated that adults have much to gain from managing cardiovascular disease risk factors such as hypertension and hypercholesterolemia. During the past two decades, studies also have made clear that atherosclerosis and other cardiovascular pathologies have life-long trajectories, and that reducing risks at an early age can reap rewards in later years. Given this background, an expert panel recently issued comprehensive guidelines on cardiovascular health and risk reduction in children and adolescents. More

Fasudil does not improve lab tests in Raynaud's phenomenon
Reuters via Medscape
The Rho-kinase inhibitor fasudil does not improve laboratory measures associated with Raynaud's phenomenon secondary to systemic sclerosis, a new study shows. Fasudil is used in Japan to treat vasospasm, and the Rho/Rho-kinase signaling pathway is important in cold-induced vasospasm, which is why the researchers had hoped the drug would help in this setting.More

Breast cancer repeat surgery less likely if pathologist present
during 1st operation

Medical News Today
The American Cancer Society estimates that this year alone, 229,060 Americans will be diagnosed with breast cancer and 39,920 patients will die from the disease. Almost one in three women with breast cancer surgery will require additional surgery, following a pathologic examination of their tumor. More

Useful apps for laboratorians
Advance for Administrators of the Laboratory
There are quite a few valuable apps that laboratorians find useful in their professional lives. CellAtlas from CellaVision is an app guide to blood cell morphology. It contains mini lectures written by hematology experts complemented by an extensive cell image database. There's also a CellQuiz game to help your memory. Here are a few others.More

Skin infection sheds light on immune cells living in our skin
Insciences Journal
Very recently, researchers discovered an important population of immune cells called memory T cells living in parts of the body that are in contact with the environment. How these "resident" memory T cells are generated was unknown, and their importance with regard to how our immune system remembers infection and how it prevents against reinfection is being studied intensively.More

Structure of virus behind foot and mouth found
Laboratory Equipment
Researchers have discovered critical new details about the structure of a virus that causes potentially fatal brain swelling and paralysis in children, pointing toward designs for antiviral drugs to treat the disease. The virus, called enterovirus 71, causes hand, foot and mouth disease, and is common throughout the world.More

Targeted prophylaxis cuts infection costs after
transrectal prostate biopsy

Reuters via Medscape
Antibiotic prophylaxis based on rectal swab cultures in men undergoing transrectal ultrasound-guided prostate biopsies might reduce post-procedure infections, and it saves money, a new study shows.More

CDC: HIV rate among US injection drug users falls
HIV infections among injection drug users in the United States have fallen by half in the past decade, but HIV testing is also down and risky behaviors such as needle-sharing persist, raising worries that progress may be short-lived, U.S. health experts said.More