ASCLS eNewsBytes
May. 26, 2015

Has the time come for integration of radiology and pathology?
DARK Daily
For years, certain pathologists and radiologists have floated the idea that an integrated diagnostic service involving both medical specialties could improve patient safety and contribute to improved patient outcomes. Now that the U.S. health care system is encouraging tighter integration of clinical services, advocates of an integrated diagnostic service involving radiology and pathology believe that the era of integrated diagnostics may be soon upon us.More

FDA recommends lifting lifetime ban on gay men donating blood
The Huffington Post
President Barack Obama's administration has recommended ending the lifetime ban on gay and bisexual men donating blood, although sexually active gay men will still face hurdles as donors. The new recommendations are contained in draft guidance issued by the Food and Drug Administration. The public will have 60 days to comment on the policy, and the FDA will later issue final rules.More

New blood tests, liquid biopsies, may transform cancer care
The Associated Press
A new type of blood test is starting to transform cancer treatment, sparing some patients the surgical and needle biopsies long needed to guide their care. The tests, called liquid biopsies, capture cancer cells or DNA that tumors shed into the blood, instead of taking tissue from the tumor itself. More

FDA and CMS form task force on LDT quality requirements
Health care providers and their patients expect that laboratory tests used in clinical management of patients should be consistent and of high quality. Under the Food and Drug Administration's proposed framework for the oversight of laboratory developed tests, outlined in draft guidance documents issued in October 2014, FDA would oversee the quality of these laboratory tests, alongside the Centers for Medicare and Medicaid Services, which regulate the laboratories themselves through the Clinical Laboratory Improvement Amendments.More

Complex signaling between blood, stem cells controls regeneration in fly gut
Buck Institute for Age Research via ScienceDaily
Having a healthy gut may well depend on maintaining a complex signaling dance between immune cells and the stem cells that line the intestine. Scientists report significant new insight into how these interactions control intestinal regeneration after an infection. More

UC Davis becomes key player in stem cell research
The Sacramento Bee
As a young girl in the 1960s, Jan Nolta traveled from her home in Willows to display her corn, grown for a 4-H project, at the California State Fair. Today, Nolta is back in the old state fair complex on Stockton Boulevard, where she oversees about 200 people working in a former exhibit building converted into a manufacturing facility for stem cells. More

Link found between breast-cancer genes, prostate cancer
The Wall Street Journal via Fox News
Mutations in two genes well known for increasing the risk of breast and ovarian cancer may also play an important role in advanced prostate cancer, researchers said, an unexpected discovery that could lead to new treatments for some men with the disease. Analysis of DNA from tumor tissue obtained from 150 men with late-stage prostate cancer revealed mutations in the BRCA1 or BRCA2 genes in about 15 percent of cases, according to a study published by the journal Cell. More

US bird flu causes egg shortage, emergency measures
As a virulent avian influenza outbreak continues to spread across the Midwestern United States, some egg-dependent companies are contemplating drastic steps — importing eggs from overseas or looking to egg alternatives. A spokeswoman for Archer Daniels Midland Co. said that as egg supplies tighten and prices rise, the food processing and commodities company has received numerous inquiries from manufacturers about the plant-based egg substitutes it makes.More

A quarter of healthy skin cells possess cancer-related mutations
Medical News Today
By performing ultra-deep genetic sequencing on 234 skin biopsies from cancer-free individuals, researchers from the Wellcome Trust Sanger Institute in the U.K. uncovered more than 100 cancer-associated mutations in every square centimeter of skin. First study author Dr. Iñigo Martincorena and colleagues found that these mutations showed patterns linked to a nonmelanoma skin cancer known as squamous cell carcinoma.More

Premature aging: Scientists identify and correct defects in diseased cells
Health Canal
Scientists from the Institut Pasteur and CNRS, in collaboration with scientists from the Institut Gustave Roussy and CEA, have succeeded in restoring normal activity in cells isolated from patients with the premature aging disease Cockayne syndrome. They have uncovered the role played in these cells by an enzyme, the HTRA3 protease. More

Mosquito sex-determining gene could help fight dengue fever
Virginia Tech via Infection Control Today
Researchers with the Fralin Life Science Institute at Virginia Tech have identified a gene responsible for sex determination in mosquitoes that can transmit yellow fever, dengue and chikungunya viruses. Only female mosquitoes bite because they need blood for developing eggs, and researchers believe that a higher ratio of males could reduce disease transmission.More

CDC: Raw tuna suspected as source of salmonella outbreak
HealthDay News
Raw tuna is suspected as the source of a salmonella outbreak that has now sickened 53 people in nine states, according to U.S. health officials. No deaths have been reported. But 10 people have been sick enough to be hospitalized, the U.S. Centers for Disease Control and Prevention said in a statement. More

Blood to feeling: Scientists turn blood into neural cells
McMaster University via Lab Manager
Scientists at McMaster University have discovered how to make adult sensory neurons from human patients simply by having them roll up their sleeve and providing a blood sample. Specifically, stem cell scientists at McMaster can now directly convert adult human blood cells to both central nervous system (brain and spinal cord) neurons as well as neurons in the peripheral nervous system (rest of the body) that are responsible for pain, temperature and itch perception.More