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Home    About    Scholarships    Meetings    Publications    Resources Jan. 4, 2011
ASCLS eNewsBytes
Jan. 4, 2011
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The 3-year outlook for diagnostics
Clinical Laboratory News    Share   Share on FacebookTwitterShare on LinkedinE-mail article
Buffeted by uncertainty and unstable economic forces, the in vitro diagnostics industry nonetheless is showing its resiliency and dynamic response to changing times, trends that will continue during the next three years. That's the collected wisdom of industry leaders asked to consider the near-term challenges and opportunities for a sector, like most of the health care industry, in flux. Even though the field is facing steep challenges, experts emphasized that circumstances are favorable for lab medicine to shine in an otherwise gloomy outlook. More

Blood test to spot cancer gets big boost from J&J
The Associated Press via Google News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A blood test so sensitive that it can spot a single cancer cell lurking among a billion healthy ones is moving one step closer to being available at your doctor's office. Boston scientists who invented the test and health care giant Johnson & Johnson said that they are joining forces to bring it to market. Four big cancer centers also will start studies using the experimental test this year. Stray cancer cells in the blood mean that a tumor has spread or is likely to, many doctors believe. A test that can capture such cells has the potential to transform care for many types of cancer, especially breast, prostate, colon and lung. More

Meet the mice with two dads
LiveScience via TODAY    Share    Share on FacebookTwitterShare on LinkedinE-mail article
To coax viable baby mice from the genes of two males, the researchers engineered cells taken from male mice so they became stem cells that could then become any tissue. Those cells are called induced pluripotent stem cells, or iPS cells. Because of natural genetic accidents, some of these male iPS cells lose their Y chromosome, becoming XO cells with a single sex chromosome instead of the typical XY genotype. More

Protein helps parasite, toxoplasma gondii, survive in host cells
ScienceDaily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers at Washington University School of Medicine in St. Louis have learned why changes in a single gene, ROP18, contribute substantially to dangerous forms of the parasite Toxoplasma gondii. The answer has likely moved science a step closer to new ways to beat Toxoplasma and many other parasites. More

Cancer stem cell theory boosted by clinical data
Medscape Medical News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The cancer stem cell hypothesis has been given a boost by new clinical data from a study in patients with acute myeloid leukemia. The new finding is reported in the American Medical Association by researchers from Stanford University, who say the clinical implications are "huge." According to the cancer stem cell theory, cancer is caused and maintained by a small group of hardy, self-renewing cells and only eradication of this cell population will lead to a cure. More

Quick tissue testing aids cholangiopancreatography yield
Reuters Health via The Doctor's Channel    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Having an on-site pathologist interpret tissue samples at endoscopic retrograde cholangiopancreatography (ERCP) can lead to immediate diagnosis, researchers report in the November 23rd on-line paper in the American Journal of Gastroenterology. Dr. Douglas A. Howell and colleagues at Maine Medical Center, Portland, and colleagues note that overall, "Techniques of tissue sampling at ERCP have been underutilized due to technical demands, low yield, and lack of immediate intraprocedural diagnosis."

Urine calcium: Laboratory measurement and clinical utility
Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Urine calcium measurement is a commonly ordered test in clinical laboratories. Unlike other urine markers, the utility of urine calcium is less clear to many laboratorians and physicians. Urine calcium can be used to assess parathyroid disease and familial hypocalciuric hypercalcemia. Although not predictive of stone formation, urine calcium is frequently elevated in patients with lithiasis. The primary clinical value of urine calcium measurement is to aid in the differential diagnoses of patients and direct optimal treatment options for patients with abnormal serum calcium. More

Cord-blood 25(OH)D levels inversely related to risk for respiratory infection
Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Cord-blood levels of 25-hydroxyvitamin D (25[OH]D) are inversely associated with the risk for respiratory tract infection and childhood wheezing but not with incident asthma, according to the results of a study reported in Pediatrics. More

Trace amounts of microbe-killing molecules predict chronic granulomatous disease survival
National Institutes of Health via EurekAlert!    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Investigators at the National Institutes of Health have observed that the survival rate of people with a rare immunodeficiency disease called chronic granulomatous disease (CGD) is greatly improved when even very low levels of microbe-killing molecules are present. Because production of these molecules, made by an enzyme called NADPH oxidase, can be predicted from genetic analysis, a patient's risk for severe CGD could be assessed very early in life, allowing for more personalized treatment, say the researchers. More

Plasma ApoE protein concentration correlates with brain amyloid burden
Medscape Medical News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The apolipoprotein E (ApoE) concentration in blood correlates with brain amyloid burden in nondemented elderly individuals, according to new data from the National Institute on Aging's Baltimore Longitudinal Study on Aging. "To the best of our knowledge, this is the first study to link plasma ApoE protein concentration with brain amyloid deposition in cognitively normal older individuals," Madhav Thambisetty, MD, PhD, from the National Institute on Aging's Clinical Research Branch in Baltimore. More
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