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Mar. 27, 2012
Mar. 27, 2012
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GIFT exome analysis unearths 2 new genes related to platelet function
Heartwire via Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The first whole exome analysis of the genome of almost 150 white patients taking part in the GRAVITAS trial has revealed two new genes that appear to be critical to platelet function. "CYP2C19*2 only explains a small portion of the overall variability in the clopidogrel response," Dr. Matthew Price. "So the question is, can we find other markers that further explain the variability? And therefore have a comprehensive genetic panel, so we can make better decisions before the procedure about which antiplatelet therapy to use?" More

Safely storing laboratory chemicals
Advance for Medical Laboratory Professionals    Share    Share on FacebookTwitterShare on LinkedinE-mail article
When looking to learn about proper chemical storage in your laboratory, consult officials who can advise you. These might include your facility's safety officer, the local fire marshal, a radiation safety officer (if you handle radioactive material), an Occupational Safety and Health Administration representative and/or an Environmental Protection Agency official (if you're disposing of unused chemicals). More

Natural history and inheritance of variegate porphyria
Journal of Clinical Pathology via Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail article
It has been suggested that King George III of Great Britain suffered from the haem biosynthetic disorder, variegate porphyria. This diagnosis is pervasive throughout the scientific and popular literature, and is often referred to as the 'Royal Malady.' The authors believe it inappropriate to view the case for porphyria purely in terms of symptoms, as has generally been the case in his presumptive acute porphyria diagnosis. Accordingly, this review provides a current description of the natural history and clinical presentation of the porphyrias, against which we measure the case for porphyria in George III and his relatives. More

Clinical pathology laboratories using new technologies to go paperless and capture all data for digital storage in laboratory information systems
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Endless flows of paper are the curse of clinical laboratories and anatomic pathology groups everywhere. Few medical laboratory organizations in the United States have successfully transitioned to a fully paperless environment. But there is good news for pathologists and clinical lab managers who feel overwhelmed by the daily flood of paper test requisitions and other documents that flow into their labs every day. Several active trends hold the potential to allow more medical laboratories to eliminate all paper and achieve a true digital working environment. More

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Repetitive-sequence-based genotyping and clonal relationship analysis of Acinetobacter baumannii in nosocomial infections
Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Rapid, reliable determination of the genetic relatedness of clinical isolates in a microbiologic laboratory is essential when investigating cases of nosocomial outbreak. Twenty-four Acinetobacter baumannii strains were collected in intensive care units from June 2008 to May 2010. The minimum inhibitory concentrations of 18 antimicrobial agents were determined for each strain. Genotyping and dendrographic analysis of A. baumannii strains were performed using the DiversiLab System. More

Viruses recruited as killers of tumors
The New York Times    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In 1951, a 4-year-old boy with leukemia contracted chickenpox. His liver and spleen, swollen by the cancer, soon returned to normal, and his elevated blood cell count fell to that of a healthy child. His doctors at the Laboratory of Experimental Oncology in San Francisco were thrilled by his sudden remission, but the blessing was short-lived. After one month, his leukemia returned and progressed rapidly until the child's death. More

New labs, new philosophies
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
R&D Magazine is proud to announce the 2012 Laboratory of the Year winners. These laboratories represent the pinnacle of design and execution in architecture for research and development. New construction facilities dominated this year's competition, but beyond this common theme none of this year's top new laboratories shared many design characteristics. One winner exemplified green and sustainable building practices. Another was built as an incubator rather than a traditional laboratory. And one was conceived and built to be one of the most advanced chemistry R&D facilities in the world. More

Hawaii poised to become the 1st state to adopt a state microbe, possibly elevating awareness of clinical and microbiology laboratories
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Not many pathologists or clinical laboratory managers know that a race is on to become the first state to adopt a specific bacterium as the official state microbe. Wisconsin tried and failed. Now Hawaii is in the race for the distinction. Hawaii's House of Representatives recently passed House Bill HB2079. This is a bill that would recognize the bacterium Nesiotobacter exalbescens as the state’s official microbe. This puts Hawaii in the running to be first to officially recognize a state microbe. More

Photoacoustic tomography bridges macroscopic, microscopic
Medscape Medical News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Photoacoustic tomography combines the best features of optical imaging and ultrasound to provide multiscale, multicontrast images of biological tissue, according to a review article published in Science. Optical techniques produce images with quality resolution and strong contrasts, but only at tissue depths up to about 1 mm, as a result of photon scattering. "Ultrasound scattering is about 1,000 times weaker than optical scattering," said lead author Lihong V. Wang, Ph.D., the Gene K. Beare Distinguished Professor of Biomedical Engineering in the School of Engineering and Applied Science at Washington University in St. Louis, in a telephone interview with Medscape Medical News. More

Introducing birth control in mosquitoes
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Female mosquitoes require energy for their egg development, which they acquire from vertebrate blood. But by sucking on blood, they become vectors of numerous disease pathogens of human and domestic animals. If the mechanisms that govern their egg production are better understood, novel approaches to controlling the reproduction and population of mosquitoes can be devised. More

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FDA lowers nucleic-acid-based TB test risk classification
Medscape Medical News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The risk classification for nucleic acid–based tests is being downgraded from class 3 (high risk) to class 2 (moderate risk) by the U.S. Food and Drug Administration (FDA), which will allow for easier approval of such tests. Class 3 device classification requires a more rigorous premarketing application and approval process. "This rule would lower the current risk classification for nucleic acid-based tests allowing manufacturers to utilize the faster, more streamlined clearance pathway for medical devices," according to the FDA. More

Gut infections are growing more lethal
The New York Times    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Gastrointestinal infections are killing more and more people in the United States and have become a particular threat to the elderly, according to new data. Deaths from the infections more than doubled from 1999 to 2007, to more than 17,000 a year from 7,000 a year, the Centers for Disease Control and Prevention reported. Of those who died, 83 percent were over age 65. More

Oncolytic Newcastle disease virus for cancer therapy
Future Microbiology via Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The idea of using bacteria and viruses for treatment of human malignancies initially stemmed from observations during the mid-1800s of tumor regressions that were associated with natural infections. Development of cell and virus culture techniques in the early 1950s led to intensive exploration of virus therapy in small animal tumor models and eventually in humans. Due to significant virulence associated with the use of some of the human pathogens, animal viruses were explored as an alternative, with Newcastle disease virus becoming a promising oncolytic agent. More

Stem cells from fat win favor with heart researcher
Reuters via The Baltimore Sun    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Stem cells derived from a patient's bone marrow can help treat severe heart failure, but the results are even better when they are taken from fat, a leading researcher said, citing his experience in a number of studies. "It's no longer a question whether the bone marrow cells work or don't work; they do work when you have healthy stem cells," Dr. James Willerson of the Texas Heart Institute said in an interview. "The search now is to find the very best stem cell type or types. More

Study:Tenecteplase seems as safe as the usual clot-busting drug
HealthDay News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A new medication called tenecteplase may be more effective at treating strokes caused by clots in large blood vessels in the brain than the current standard therapy, Australian researchers report. More

Statins in the time of heart damage
Reuters    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Patients who view images of their hearts and see for themselves the buildup of calcium within their artery walls become more compliant about taking their cholesterol-fighting drugs and are more likely to lose weight, researchers said. The finding resulted from two studies presented at the annual scientific sessions of the American College of Cardiology in Chicago. More
CellaVision Automates and Standardizes the Manual Differential

CellaVision introduces CellAtlas®, the perfect way to learn the basics of hematology cell morphology. This App for the Apple iPhone and iPod Touch compliments our digital cell morphology portfolio, and is an educational tool to assist in the recognition and classification of blood cells, by utilizing mini-lectures and cell quizzes. More
Triturus - True Open Flexibility
As a leader in fully automated immunoassay testing systems, Grifols USA Diagnostic Division’s premier product, the TRITURUS® ELISA System is an open, fully automated, multi-test and multi-batch immunoassay system. Grifols USA is a major distributor of quality IVD ELISA tests for Infectious Disease, Autoimmune Diseases and many other disease states. Grifols’ Diagnostic products take the complexity out of clinical diagnostic testing.

Trust in Cleveland Clinic Laboratories
Cleveland Clinic Laboratories is a full-service, national reference lab dedicated to providing world class care. We have a dedicated staff of more than 1,300 employees, including board-certified subspecialty pathologists, PhDs, technologists, technicians, and support personnel. Cleveland Clinic Laboratories is proud to serve hospitals, outpatient facilities and physician offices worldwide. For more information, please visit
Structured data capture for non-interfaced labs

Learn how Aurora Advanced Healthcare is using LabDE to improve lab data entry workflow and increase data interoperability. LabDE automatically recognizes and highlights blocks of crucial text, including test name, code, value units, reference range and flags, and incorporates these fields as structured data into the EHR/LIS. Watch the video.
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