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Apr. 10, 2012
Apr. 10, 2012
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The promise and power of next-generation sequencing
Clinical Laboratry News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
What is commonly known as next-generation genetic sequencing made its debut just seven years ago with the first published report of a commercially available platform being used to dramatically boost throughput in comparison to existing methods. Since then, the scientific literature has been brimming with NGS-related studies, and the technology is very rapidly on its way to replacing the current molecular diagnostic gold standard, Sanger sequencing, a technology developed in the 1970s. More

Updated guidelines for cervical cancer screening: Less is more
Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Andrew Kaunitz, professor and associate chair of the Department of Obstetrics and Gynecology at the University of Florida College of Medicine in Jacksonville, discusses the impact annual pap smears have made in reducing the incidence of and the mortality from cervical cancer represents a triumph of preventive medicine. More

Beyond the microscope
Advance for Medical Laboratory Professionals    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Microscopy defines the world of cytology. This has traditionally been the primary association when it comes to our profession, and it still is to a great extent. The most common application of cytopathology is the Pap smear, used as a screening tool to detect precancerous and cancerous gynecologic lesions. This approach still relies on the basic tool of the profession, and a meaningful diagnosis can now be supported by a variety of approaches. More

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Detecting breast cancer's fingerprint in a droplet of blood
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
One-in-8 women will be diagnosed with breast cancer during her lifetime. The earlier cancer is detected, the better the chance of successful treatment and long-term survival. However, early cancer diagnosis is still challenging as testing by mammography remains cumbersome, costly, and in many cases, cancer can only be detected at an advanced stage. More

Clinical pathology laboratories beef up courier and logistics services to deliver more value to client physicians
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Medical laboratories gain competitive advantage by using GPS and real-time vehicle tracking to improve performance of their couriers. Like everything else in laboratory medicine, even such once-simple operational areas as logistics and courier services are becoming complicated — and more expensive. The reasons are familiar to all clinical laboratory managers and pathologists. More

Live and in color: How to track RNA in living cells
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Even with the amazing array of tools available to biologists studying cellular functions, watching these processes unfold inside a living cell remains a challenge. Green fluorescent protein revolutionized imaging and the spatial understanding of how proteins interact within living cells, but a lot of information is also embedded within the production, processing, and manifold interactions of RNA. More

Two-thirds of mupirocin-resistant MRSA wrongly treated
Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Two-thirds of patients with high-level mupirocin-resistant, methicillin-resistant Staphylococcus aureus are receiving the wrong treatment because of an inefficient process for reporting sensitivity results. The findings highlight the widespread need for electronic, integrated systems to improve appropriate and timely prescribing and to prevent development of nosocomial MRSA infections, along with the further development of resistance, according to a study. More

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Scientists link gene mutation to autism risk
The New York Times    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Teams of scientists working independently have for the first time identified several gene mutations that they agree sharply increase the chances that a child will develop autism. They have found further evidence that the risk increases with the age of the parents, particularly in fathers over age 35. The gene mutations are extremely rare and together account for a tiny fraction of autism cases — in these studies, only a handful of children. Experts said the new research gave scientists something they had not had: a clear strategy for building some understanding of the disease's biological basis. More

New stem cells could aid transplant studies
Laboratory Equipment    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers have generated a new type of human stem cell that can develop into numerous types of specialized cells, including functioning pancreatic beta cells that produce insulin. Called endodermal progenitor cells, the new cells show two important advantages over embryonic stem cells and induced pluripotent stem cells: they do not form tumors when transplanted into animals, and they can form functional pancreatic beta cells in the laboratory. More

NIH appoints Gary Gibbons as next director of the NHLBI
Forbes    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Gary Gibbons will be the next Director of the National Heart, Lung, and Blood Institute (NHLBI). The selection of Gibbons was announced by the National Institutes of Health Director Francis Collins. Gibbons is the founder and current director of the Cardiovascular Research Institute, chairperson of the Department of Physiology, and professor of physiology and medicine at the Morehouse School of Medicine in Atlanta. More

A virus may make mosquitoes even thirstier for human blood
The New York Times    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The dengue virus may actually make mosquitoes thirstier for human blood, new research has found. In a study published last week in PLoS Pathogens, mosquito experts at the Johns Hopkins Bloomberg School of Public Health found that the dengue virus altered the production of proteins made by 147 different genes. More

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Genes found to increase childhood obesity risk
CNN    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers have identified two genetic variations that appear to increase the risk of childhood obesity. The study authors took data from North American, Australian and European meta-analysis of 14 studies consisting of 5,530 obese children and 8,318 non-obese kids. The team compared the genetic data. More

Keeping chilly lab mice warm: Key to better science?
ABC News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Joseph Garner imagines how much happier and healthier lab mice would be in a kinder, gentler environment than the stark cages in chilly laboratories — and how that, in turn, might improve the outcome of research that underlies human medical advances. He has focused on a simple fact: Mice are chronically cold and suffer from thermal stress. More
CellaVision Automates and Standardizes the Manual Differential

CellaVision introduces CellAtlas®, the perfect way to learn the basics of hematology cell morphology. This App for the Apple iPhone and iPod Touch compliments our digital cell morphology portfolio, and is an educational tool to assist in the recognition and classification of blood cells, by utilizing mini-lectures and cell quizzes. More
Triturus - True Open Flexibility
As a leader in fully automated immunoassay testing systems, Grifols USA Diagnostic Division’s premier product, the TRITURUS® ELISA System is an open, fully automated, multi-test and multi-batch immunoassay system. Grifols USA is a major distributor of quality IVD ELISA tests for Infectious Disease, Autoimmune Diseases and many other disease states. Grifols’ Diagnostic products take the complexity out of clinical diagnostic testing.

Trust in Cleveland Clinic Laboratories
Cleveland Clinic Laboratories is a full-service, national reference lab dedicated to providing world class care. We have a dedicated staff of more than 1,300 employees, including board-certified subspecialty pathologists, PhDs, technologists, technicians, and support personnel. Cleveland Clinic Laboratories is proud to serve hospitals, outpatient facilities and physician offices worldwide. For more information, please visit
Structured data capture for non-interfaced labs

Learn how Aurora Advanced Healthcare is using LabDE to improve lab data entry workflow and increase data interoperability. LabDE automatically recognizes and highlights blocks of crucial text, including test name, code, value units, reference range and flags, and incorporates these fields as structured data into the EHR/LIS. Watch the video.
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