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Apr. 24, 2012
Apr. 24, 2012
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New map of breast cancer identifies
10 disease subtypes

Medscape Medical News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A "new map" of breast cancer, which identifies 10 distinct disease subtypes based on gene activity, will revolutionize the diagnosis and treatment of this disease, say researchers. The findings, published in Nature, come from the largest global gene study of breast cancer tissue ever performed. "This research is 'ground-breaking' indeed," said world-renowned breast cancer expert Martine Piccart, M.D., Ph.D., from the Jules Bordet Institut in Brussels, Belgium. More
Related stories:
Breast cancer: Not 1 disease but 10   (TIME)
Doctors redefine breast cancer into 10 subtypes in study   (Bloomberg Businessweek)

Researchers: Artificial DNA can replicate in lab
Bloomberg    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists moved a step closer to synthesizing new life forms in the laboratory after researchers showed that artificial genetic material called XNA can be replicated in the test tube much like real DNA. More

10 ways to improve the quality of send-out testing
Clinical Laboratory News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
During the past decade, send-out test volumes have grown steadily in many laboratories. This trend can be attributed to increases in the number of available tests, especially genetic tests, as well as proprietary tests that must be sent to specific laboratories. These tests involve more steps and more manual processes than in-house tests, thereby increasing the risk of errors that can cause patient harm. More

With flat budget proposed, clamor builds in Congress for more NIH spending
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
This election year wouldn't appear to offer much hope for real year-over-year growth in the National Institutes of Health budget, with both sides of the political spectrum attacking sky-high federal spending. President Barack Obama is proposing to keep NIH's budget flat in FY 2013 at $30.702 billion in discretionary budget authority from Congress and $30.86 billion in overall program level funding. Yet two bipartisan "Dear Colleague" letters circulating in Congress in recent weeks have drawn many more signatures than most. Their message is that NIH spending should grow well above the current fiscal year's level. More

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Will blocking cannabinoid receptors help PTSD?
Medscape Medical News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
New brain imaging research showing increased cannabinoid receptors in the brains of patients with posttraumatic stress disorder (PTSD) suggests a potential treatment target for the disorder. More

Chronic disease management program in New York City uses EHRs to help physicians improve patient care
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Seven years into a targeted program to use clinical data to drive measurable improvement in the health of patients with chronic diseases, health officials in New York City are declaring the effort to be successful at meeting several important goals. Some healthcare experts say NYC's innovative project provides valid insight into the future of American healthcare. Some pathologists and clinical laboratory managers are already familiar with what is called the Primary Care Information Project, organized and manage by the New York City Department of Health and Mental Hygiene. More

Searching for a superbug's secret weapon
Nature    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers have identified a gene that makes some strains of an antibiotic-resistant bacterium more virulent, and have found that the gene is becoming more prevalent. Epidemics of infection with methicillin-resistant Staphylococcus aureus come in waves. More

How to track RNA in living cells
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Even with the amazing array of tools available to biologists studying cellular functions, watching these processes unfold inside a living cell remains a challenge. Green fluorescent protein revolutionized imaging and the spatial understanding of how proteins interact within living cells, but a lot of information is also embedded within the production, processing, and manifold interactions of RNA. More

Hospitals see decline in care-related infections
Reuters    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The United States is making progress in reducing the spread of infections to patients while they are in the hospital, the Centers for Disease Control and Prevention said. Twenty-one states reported reductions in so-called "central line" bloodstream infections from 2009-2010, according to the federal health agency, which used data from a state-by-state tracking system. More

Measles: 2011 was the worst in the US in 15 years
TIME    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Measles was declared eliminated in the United States in 2000. But a report released recently by the Centers for Disease Control and Prevention says infections have risen: last year the U.S. reported the highest number of measles cases in 15 years. More

Cancer research compromised by bad cells
UPI    Share    Share on FacebookTwitterShare on LinkedinE-mail article
As many as 20 percent of cancer cell lines included in repositories for use by researchers may be improperly identified, a U.S. researcher said. John Masters, a professor of experimental pathology at University College London, said finding a cure for cancer might be hampered by the inaccurately labeled cancer cell lines that comprise research. More

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Texas Health Presbyterian Hospital Dallas:
2012 Laboratory of the Year

Advance for Medical Laboratory Professionals    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Texas Health Presbyterian Hospital Dallas, a full-service hospital lab with 128 employees, nine pathologists and 1.5 million tests a year, strives for excellence in all areas. They've improved turnaround time and employee engagement, are involved in community service projects and take initiative to improve physician satisfaction — and so much more. More

Managing chemical inventory
Lab Manager Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The old proverb "The more things change, the more they stay the same" seems truer than ever. Certainly, the use of technology in the lab is making significant changes to laboratory work processes, but when all is said and done, the goals of the lab remain basically the same. It is how these goals are achieved — particularly through the use of technology — that is driving change in the lab. This article focuses on how technology is changing the lab in the realm of chemical inventory management. More

Diet may treat some gene mutations
Advance for Medical Laboratory Professionals    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists have determined variations and responses to vitamin treatment in the human cystathionine beta synthase gene, which when defective, causes the disease homocystinuria, an inherited metabolic disorder sometimes treatable with vitamin B6. After the analysis, scientists correlated specific gene mutations with severity of the disease, ranging from perfectly healthy and functional to severe and untreatable. Although the current study focused on homocystinuria, testing the effects of naturally occurring gene variations using surrogate organism genetics can be applied to other inherited disorders, such as neural tube defect, cleft palate and blindness. More

Self-testing for bacterial vaginosis is accurate
Medscape Medical News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Self-tests for bacterial vaginosis are reasonably accurate (73 percent sensitive and 67 percent specific for a pH-based test and 40 percent sensitive and 90 percent specific for a self-sialidase test when compared with a clinical diagnosis using modified Amsel criteria). The pH-based test has been available over the counter since 2001 and may be useful when pelvic exams are not feasible. The self-sialidase test received a waiver from the Clinical Laboratory Improvement Amendments and has been marketed by physicians since 2004. More
CellaVision Automates and Standardizes the Manual Differential

CellaVision introduces CellAtlas®, the perfect way to learn the basics of hematology cell morphology. This App for the Apple iPhone and iPod Touch compliments our digital cell morphology portfolio, and is an educational tool to assist in the recognition and classification of blood cells, by utilizing mini-lectures and cell quizzes. More
Triturus - True Open Flexibility
As a leader in fully automated immunoassay testing systems, Grifols USA Diagnostic Division’s premier product, the TRITURUS® ELISA System is an open, fully automated, multi-test and multi-batch immunoassay system. Grifols USA is a major distributor of quality IVD ELISA tests for Infectious Disease, Autoimmune Diseases and many other disease states. Grifols’ Diagnostic products take the complexity out of clinical diagnostic testing.

Trust in Cleveland Clinic Laboratories
Cleveland Clinic Laboratories is a full-service, national reference lab dedicated to providing world class care. We have a dedicated staff of more than 1,300 employees, including board-certified subspecialty pathologists, PhDs, technologists, technicians, and support personnel. Cleveland Clinic Laboratories is proud to serve hospitals, outpatient facilities and physician offices worldwide. For more information, please visit
Structured data capture for non-interfaced labs

Learn how Aurora Advanced Healthcare is using LabDE to improve lab data entry workflow and increase data interoperability. LabDE automatically recognizes and highlights blocks of crucial text, including test name, code, value units, reference range and flags, and incorporates these fields as structured data into the EHR/LIS. Watch the video.
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