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ASCLS eNewsBytes
June. 28, 2011
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hs-CRP: What is proven and unproven?
Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A recent large meta-analysis of genome-wide association studies from 15 cohort studies comprising 66,185 subjects and a replication sample of 16,540 subjects identified 18 gene loci associated with C-reactive protein (CRP) levels. These 18 gene loci were mostly associated with immune response and metabolic regulatory pathways involved in the regulation of chronic inflammation. More

Saxagliptin effective with less hypoglycemia than glipizide
Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail
Saxagliptin demonstrated reductions in glycosylated hemoglobin (HbA1c) and fasting plasma glucose that were similar to those seen with the sulfonylurea drug glipizide, when both were added to metformin, but it had a lower risk for hypoglycemia and led to more weight loss in patients with type 2 diabetes, according to a long-term study. More

In search of the memory molecule, researchers discover key protein complex
ScienceDaily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Have a tough time remembering where you put your keys, learning a new language or recalling names at a cocktail party? New research from the Lisman Laboratory at Brandeis University points to a molecule that is central to the process by which memories are stored in the brain. More

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Pharmacogenomics of warfarin: Clinical implications
Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail article
There is currently a wealth of data surrounding genetic polymorphisms in 2 genes, CYP2C9 and VKORC1, and how these specific polymorphisms affect variation in warfarin dose requirements, international normalized ratio control during warfarin initiation, and, for certain variants, bleeding outcomes in patients treated with warfarin. The strength of this evidence prompted the U.S. Food and Drug Administration (FDA) to update the drug label for warfarin in 2007 and then again in January 2010 with recommendations for initiation dose modifications in carriers of the specific CYP2C9 and VKORC1 variants. More

Human cells fitted with synthetic signaling cascade
ScienceDaily    Share    Share on FacebookTwitterShare on LinkedinE-mail
Researchers from ETH Zurich have fitted human cells with a synthetic signaling cascade that can be used to switch on and regulate genes via blue light. This "gene light switch" makes interesting therapies possible, which could be used to treat type 2 diabetes, for instance. More

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Morphological heterogeneity of oral salivary gland carcinomas
International Journal of Clinical and Experimental Pathology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers analyzed 41 oral salivary gland carcinomas from consecutive 290 salivary gland carcinoma database (14 percent) with emphasis on the histological spectrum and clinical outcome of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. The cohort included 14 ACCs, 14 mucoepidermoid carcinomas, eight PLGAs, three adenocarcinomas, not otherwise specified and two acinic cell carcinomas. More

Doctors make breakthrough in repairing genetic defects
The Guardian    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Doctors have treated a life-threatening blood disease by repairing flaws in the genetic code of a living animal, the first time such an ambitious feat has been achieved. The work raises the prospect of powerful new therapies that can target and repair the genetic defects behind a wide range of human diseases that cannot be tackled with modern medicines. More

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'Lean gene' ups risk of heart disease and diabetes
Reuters    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Being slim may not always lead to a lower risk of heart disease and diabetes, scientists said after they identified a gene linked both to having a lean body and to a higher risk of metabolic diseases. More

Bile duct cancer from liver fluke infection
Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Infection with the parasitic liver fluke Opisthorchis viverrini does not always lead to bile duct cancer, but nearly all cases of cholangiocarcinoma develop in individuals with this infection. Hence, the liver flukes are officially classified by the World Health Organization as Group 1 carcinogens. More

Almost 2.8 million receive HIV tests in CDC program
Medscape    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A three-year program to expand access to HIV testing has diagnosed 18,432 individuals in high-risk areas who were previously unaware of their HIV status, the Centers for Disease Control and Prevention (CDC) announced recently. The $111 million program provided almost 2.8 million HIV tests; the CDC provided funds to 25 local health departments in areas with high HIV infection rates. More

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Woman's skin cells used in Long QT Syndrome research
Wisconsin State Journal    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A skin sample from Helen Eckert, transformed into a colony of heart cells in a University of Wisconson-Madison lab, could give scientists clues to what causes Long QT Syndrome, a genetic heart disease. Eckert, 69, from Lake Mills, Wis., has the condition that causes an irregular heartbeat and can lead to sudden death. She was the first of three patients with the condition who donated skin cells for stem cell research on campus. More
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CellaVision Automates and Standardizes the Manual Differential

CellaVision introduces CellAtlas®, the perfect way to learn the basics of hematology cell morphology. This App for the Apple iPhone and iPod Touch compliments our digital cell morphology portfolio, and is an educational tool to assist in the recognition and classification of blood cells, by utilizing mini-lectures and cell quizzes.
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