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Home    About    Scholarships    Meetings    Publications    Resources Dec. 21, 2010
ASCLS eNewsBytes
Dec. 21, 2010
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Use of Lean by clinical pathology laboratories continues to be important trend in laboratory medicine
DARK Daily    Share   Share on FacebookTwitterShare on LinkedinE-mail article
One major trend in laboratory medicine still gathering momentum is the use of Lean and similar process improvement methods by clinical laboratories and pathology groups cross the nation. However, once a medical laboratory has enjoyed substantial gains from initial Lean projects, it can be challenging to sustain the Lean mindset with staff and further build upon those gains. More

Researchers grow insulin-producing cells from testes
WebMD    Share    Share on FacebookTwitterShare on LinkedinE-mail article
New research suggests it may be possible for people with type 1 diabetes to grow their own insulin-producing cells — an advancement that could lead to a cure for this form of diabetes. … Islet cells in the pancreas are responsible for producing insulin, but these cells are destroyed in people with type 1 diabetes. More

Protein disables P53, drives breast cells toward cancer transition
ScienceDaily    Share    Share on FacebookTwitterShare on LinkedinE-mail
The recently identified TRIM24 protein plays an active role in pushing normal breast cells into rapid cell proliferation and, potentially, into breast cancer. Reporting in the journal Nature, a team led by researchers at The University of Texas MD Anderson Cancer Center found that TRIM24 (tripartite motif-containing 24) pushes estrogen-responsive genes toward active expression. More

Study investigates germline mutations associated with pheochromocytomas
Medscape Medical News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
An international collaborative study investigating the prevalence and genetic association of FP/TMEM127 mutations with chromaffin cell tumors has found an association with pheochromocytomas, but not with paragangliomas. The mutations cause abnormal intracellular distribution of the protein encoded by the gene. The report in the Journal of the American Medical Association, also noted that germline mutations of FP/TMEM127 are present in patients in their 40s — an age not commonly included in genetic screenings associated with the diagnosis. More

Synthetic riboswitches turn on bacterial genes
Infection Control Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists show that synthetic riboswitches can control gene expression in a wide variety of bacteria, including some organisms in which such control has been difficult. The research is published in the December 2010 issue of the journal Applied and Environmental Microbiology. Bacteria regulate their metabolism using riboswitches, sequences of RNA that alter gene expression when they bind a small-molecule metabolite. In earlier work, Justin P. Gallivan's laboratory at Emory University in Atlanta created synthetic riboswitches, which the researchers can use to turn specific genes on or off, to control what the cell does. More

Cholera vaccination in Haiti not possible until spring
NPR    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Experts emerged from an emergency session at the Pan American Health Organization saying that Haiti should get cholera vaccine. But they say it won't happen until next spring at the earliest. The planet's supplies of cholera vaccine are so tight that it will take a long time before vaccination can reach a sizable fraction of Haiti's 9 million people — not to mention the 10 million next door in the Dominican Republic. More

Staph's trail points to human susceptibilities
The New York Times    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists have finally found an answer to one of the great mysteries about the most deadly bacteria, Staphylococcus aureus — why it attacks primarily humans and not animals. And they now have an idea of why some humans are particularly susceptible to these bacteria that kill 100,000 Americans a year, far more than any other microbe. More

1 in 6 Americans gets food-borne illness
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The first government estimates of food-borne illnesses in a decade find that one in six Americans gets sick, 128,000 people are hospitalized, and 3,000 people die each year after eating tainted food. "These illnesses are associated with billions in health care costs and also have a substantial human cost in severe illnesses and in some cases, long-term health effects that linger after the initial illness subsides," says Christopher Braden, MD, acting director of the CDC's Division of Foodborne, Waterborne and Environmental Diseases. "We need to do more to lower the impact of these diseases in the United States." More

Alzheimer's disease plasma proteomics data made available
Medscape Medical News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The global Alzheimer's disease scientific research community received an early present this holiday season: results of a proteomics study using plasma samples from the Alzheimer's Disease Neuroimaging Initiative (ADNI), the largest public-private partnership to date in Alzheimer's disease research. The ADNI has been "very powerful for validating biomarkers for Alzheimer's disease," said John Q. Trojanowski, MD, Phcodirector of the ADNI Biomarker Core at the University of Pennsylvania, Philadelphia. More

Microbiology of ascending lymphangitis
Medscape Pathology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A 73-year-old, white man presented to the emergency department with a draining wound on his right hand and erythematous subcutaneous nodules tracking up his right forearm. He stated that he sustained the wound to his hand during a traumatic injury while hammering in his barn three days prior to presentation. He was treated at another hospital with clindamycin, levofloxacin, and vancomycin, after which he demonstrated only mild improvement. His medical history was significant for long-term steroid use for pulmonary hemosiderosis. The patient was taken to surgery for incision and drainage of the hand wound. Specimens were sent for culture and direct examination. More
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