ASTS NewsBrief
Jan. 13, 2014

Why a woman's heart won't work in a man's body
Everyday Health
Men who get undersized female hearts are more likely to die within a year of having a heart transplant, according to data gathered by the United Network for Organ Sharing (UNOS). In a first-of-its-kind study, physicians at the University of Maryland's School of Medicine analyzed 31,634 donor-recipient heart transplant pairs using the UNOS transplant registry.More

Make your voice heard!
ASTS
If you have not already responded to the member survey, please do so at https://www.surveymonkey.com/s/BXX8W2H. This is your chance to weigh in on important issues the Council will be addressing as they finalize the strategic plan for the Society. It is only 5 questions and should take less than 5 minutes of your time. Your input is appreciated!More

2014 ASTS Research Grants open
ASTS
ASTS research grant applications will be accepted until Feb. 4, 2014. Complete eligibility requirements and the applications are available online at ASTS.org. More

Reminder: Have you paid your dues?
ASTS
ASTS members should have received their membership renewal invoices via email late last year. Dues payments were due at the end of the year, but you can still pay online and ensure your continued access to the wide range of ASTS member benefits, including your AJT subscription and discounted registration to events like the 2014 WTC. You can log on to the ASTS website anytime to pay your dues. More

New obesity guidelines promise and potential
Journal of the American Medical Association (login required)
Obesity is a major contributor to many chronic diseases and, because more than 1 in 3 US adults are obese, a public health challenge. The goal of new obesity guidelines is to help primary care clinicians manage obesity more effectively. Obesity 2 (published as "2013 ACCF/AHA/TOS Guidelines for the Management of Overweight and Obesity in Adults") has been long awaited. More

Automated image analysis method for detecting and quantifying macrovesicular steatosis in hematoxylin and eosin-stained histology images of human livers
Liver Transplantation (login required)
Large-droplet macrovesicular steatosis (ld-MaS) in more than 30 percent of liver graft hepatocytes is a major risk factor for liver transplantation. An accurate assessment of the ld-MaS percentage is crucial for determining liver graft transplantability, which is currently based on pathologists' evaluations of hematoxylin and eosin (H&E)–stained liver histology specimens, with the predominant criteria being the relative size of the lipid droplets (LDs) and their propensity to displace a hepatocyte's nucleus to the cell periphery. Automated image analysis systems aimed at objectively and reproducibly quantifying ld-MaS do not accurately differentiate large LDs from small-droplet macrovesicular steatosis and do not take into account LD-mediated nuclear displacement; this leads to a poor correlation with pathologists' assessments.More

Outcomes of long storage times for cryopreserved vascular grafts in outflow reconstruction in living donor liver transplantation
Liver Transplantation (login required)
The outflow reconstruction of the right anterior sector in a right liver graft with cryopreserved vascular grafts is crucial for preventing graft congestion in living donor liver transplantation. The impact of the duration of cryopreservation has not been evaluated so far. More

The extent and predictors of waiting time geographic disparity in kidney transplantation in the United States
Transplantation (login required)
Waiting time to deceased donor kidney transplant varies greatly across the United States. This variation violates the final rule, a federal mandate, which demands geographic equity in organ allocation for transplantation.More

Postanastomotic transplant renal artery stenosis: Association with de novo class II donor-specific antibodies
American Journal of Transplantation
In this study, we analyze the outcomes of transplant renal artery stenosis (TRAS), determine the different anatomical positions of TRAS, and establish cardiovascular and immunological risk factors associated with its development. One hundred thirty-seven of 999 (13.7 percent) patients had TRAS diagnosed by angiography; 119/137 (86.9 percent) were treated with angioplasty, of which 113/137 (82.5 percent) were stented.More

Trajectories of perceived benefits in living kidney donors: Association with donor characteristics and recipient outcomes
Transplantation (login required)
While improved health of the recipient may serve as a primary motivating factor, living kidney donors also may expect to accrue some personal benefit following donation. This study sought to identify trajectories of perceived benefit over the first two years after donation.More

Swedish doctors transplant wombs into 9 women
The Associated Press via WFAA-TV
Nine women in Sweden have successfully received transplanted wombs donated from relatives and will soon try to become pregnant, the doctor in charge of the pioneering project has revealed. More