ASTS NewsBrief
Jan. 26, 2015

Sirolimus use and cancer incidence among US kidney transplant recipients
American Journal of Transplantation (login required)
Sirolimus has anti-carcinogenic properties and can be included in maintenance immunosuppressive therapy following kidney transplantation. We investigated sirolimus effects on cancer incidence among kidney recipients. The US transplant registry was linked with 15 population-based cancer registries and national pharmacy claims. Recipients contributed sirolimus-exposed time when sirolimus claims were filled, and unexposed time when other immunosuppressant claims were filled without sirolimus. More

Nominations for ASTS committees close next week
Nominations for ASTS Committees close at 5 p.m. Eastern on Monday, Feb. 2. You can nominate yourself or someone else you feel is a good fit for a particular committee. More

FQAPI webinar Jan. 30
Please join ASTS, AST, and representatives from the CMS Survey and Certification Group as we review the Focused Quality Assessment and Performance Improvement Survey (FQAPI) program and plans for 2015. The webinar will highlight the link between QAPI and the mitigating factors process, and introduce an upcoming CMS QAPI webinar series. This webinar is complimentary and open to all transplant professionals.More

Chimera 2015 winter issue available
ASTS is pleased to announce that the latest issue of the Chimera is now available online.More

Cardiovascular risk and events after liver transplantation: Experiences from 313 consecutive transplants with a follow up of 20 years
Clinical Transplantation (login required)
Cardiovascular diseases (CVD) are the third leading cause of late death after liver transplantation (LT). The old-PROCAM score was described in males (aged 35-65 years) to estimate cardiovascular events after LT. New-PROCAM is now available to estimate risks for cardiovascular events in both genders and for a wider age range (25-75 years). We tested old- and new-PROCAM in long-term follow up (10 and 20 years) and describe CVD risk factors, kidney function and immunosuppression over two decades. More

Researcher to test organ-cooling device to protect human livers for transplant
An organ-cooling device that preserves livers from pigs might protect human livers for transplantation, a discovery that could help save untold lives, a University of Pittsburgh researcher said. Dr. Paulo Fontes said UPMC Presbyterian and Montefiore in Oakland could run the first human trial of the method this year and enlist 10 liver transplant patients to start, pending approval from the federal Food and Drug Administration.More

Variation in biliary complication rates following liver transplantation: Implications for cost and outcome
American Journal of Transplantation (login required)
Although biliary complications (BCs) have a significant impact on the outcome of liver transplantation (LT), variation in BC rates among transplant centers has not been previously analyzed. BC rate, LT outcome and spending were assessed using linked Scientific Registry of Transplant Recipients and Medicare claims (n = 16 286 LTs). Transplant centers were assigned to BC quartiles based upon risk-adjusted observed to expected (O:E) ratio of BC separately for donation after brain death (DBD) and donation after cardiac death (DCD) donors.More

Liver regeneration after living donor transplantation: Adult-to-adult living donor liver transplantation cohort study
Liver Transplantation
Adult-to-adult living donors and recipients were studied to characterize patterns of liver growth and identify associated factors in a multicenter study. Three hundred and fifty donors and 353 recipients in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) receiving transplants between March 2003 and February 2010 were included. Potential predictors of 3-month liver volume included total and standard liver volumes (TLV and SLV), Model for End-Stage Liver Disease (MELD) score (in recipients), the remnant and graft size, remnant-to-donor and graft-to-recipient weight ratios (RDWR and GRWR), remnant/TLV, and graft/SLV.More

Sofosbuvir, ribavirin prevented recurrent HCV infection after liver transplant
Sofosbuvir and ribavirin administered before liver transplantation prevented posttransplantation recurrence of hepatitis C infection, according to new research data. "Patients with hepatitis C virus at the time of liver transplantation (LT) universally experience recurrent HCV infection," Michael P. Curry, M.D., from Beth Israel Deaconess Medical Center in Boston, said in a press release. "Recurrent HCV infection follows an aggressive course. More

Is there a moral way to fix America's kidney shortage?
The Atlantic
The exchange of kidneys represents what economists call a repugnant market: it could be made more efficient if people were allowed to pay for them, but there are ethical concerns about introducing money into the equation. As demand far outstrips supply — the average wait for a kidney has climbed to 4.5 years — there's an increasing call for establishing a regulated organ market.More

Hospital shares live kidney transplant on Twitter, Vine
Access to a hospital operating room during surgery is typically limited to professionals, but the University of Utah is opening its hospital up to the public through social media. The entire process of a kidney transplant is being shared live Wednesday by the U. healthcare team using the hashtag #ColinsKidney. Colin Warren, a 51-year-old Wal-Mart executive, is donating his left kidney to his father-in-law Gary, according to the hospital. Live coverage of the surgery extended to Twitter, Vine and Instagram, letting people see the entire process of the kidney being removed from Warren and transplanted into his father-in-law. More