ASTS NewsBrief
Sep. 9, 2013

Test could warn of problems for kidney transplant recipients
A simple test might reveal whether a kidney transplant recipient is at imminent risk of organ rejection. A study finds that the test, which checks urine levels of an immune protein, might lessen the need for kidney biopsies in some patients and pinpoint others who might safely reduce their dose of immune-suppressing drugs. More

OPTN Proposals for Public Comment
OPTN/UNOS issued six new proposals for public comment on Friday, Sept. 6. The comment period will close Dec. 6, 2013.More

Donor Management Research Conference Sept. 16-17
The Organ Donation and Transplantation Alliance, through a cooperative agreement with HRSA, is pleased to offer the Donor Management Research Consensus Conference Sept. 16-17, 2013, in the Washington, D.C. area. This meeting will allow members of the DTCP to come together to identify challenges that the community has identified related to donor management research. More

HCC in Liver Transplantation: Appearances Are Everything Defining Imaging Characteristics for HCC in Liver Transplantation
UNOS will hold a webinar on Wednesday, Oct. 2, from 2 to 3 p.m. Eastern to explain and discuss upcoming changes to Policy and how these changes will affect HCC exception applications.More

Kidney transplant recipient with BK virus infection: Practice points for clinicians
Medscape (login required)
This interview with Dr. Simon Goral and Dr. Sundaram Hariharan, is part of program that includes a discussion of the off-label use of leflunomide, cidofovir, intravenous immune globulin (IVIG), and fluoroquinolone antibiotics for the treatment of polyomavirus BK (BKV) infection.More

Coordinating unspecified living kidney donation and transplantation across the blood-type barrier in kidney exchange
Transplantation (login required)
This article studies multicenter coordination of unspecified living kidney donation and transplantation across the blood-type barrier in kidney exchange. Important questions are whether such coordination should use domino paired donation or nonsimultaneous extended altruistic donor chains, what the length of the segments in such chains should be, when they should be terminated, and how much time should be allowed between matching rounds. Furthermore, it is controversial whether the different modalities should be coordinated centrally or locally and independently.More

China: Organ transplant program will phase out executed inmates
Reuters via The New York Times
China will start phasing out its long-held practice of using the organs of executed prisoners for transplant operations in November, a senior official said recently, as it pushes to mandate the use of organs from ethical sources in hospitals.More

The use of transient elastography and non-invasive serum markers of fibrosis in pediatric liver transplant recipients
Pediatric Transplantation (login required)
The use of non-invasive markers to diagnose liver allograft fibrosis is not well established in children after LTx. TE, FT, and ELF score were performed in 117 liver-transplanted children (60M, 8.9 [0.5–18.5] yr) and 336 healthy controls. Liver biopsy was available in 36 children. Results of histology and non-invasive markers were compared using correlation coefficient or Mann–Whitney U-test as appropriate. TE correlated best with histological degree of fibrosis.More

Safe use of highly steatotic livers by utilizing a donor/recipient clinical algorithm
Clinical Transplantation (login required)
The aim of this study was to assess the long-term safety and clinical outcomes associated with the utilization of highly steatotic donor livers utilizing a specific donor/recipient matching algorithm. This was a prospective, observational, single-center, 10-year follow-up studyMore

Regulation of molecular pathways in ischemia-reperfusion injury after liver transplantation
Transplantation (login required)
Ischemia-reperfusion (I/R) injury is a multifactorial phenomenon that occurs during the transplant event and frequently compromises early graft function after liver transplantation (LT). Current comprehension of molecular mechanisms and regulation processes of I/R injury lacks clarity. MicroRNA (miRNA) regulation results critical in several biological processes.More

Implantable, artificial kidney: Shuvo Roy, Ph.D.
Renal & Urology News
Shuvo Roy, Ph.D., a bioengineering professor at the University of California, San Francisco, is developing an artificial kidney that could change the lives of millions of people around the world.More