ASTS NewsBrief
Oct. 6, 2014

Mayo finds many liver transplant patients can avoid costly stay in ICU after surgery
Medical Xpress
The liver transplant team at Mayo Clinic in Florida has found, based on 12 years of experience, that more than half of patients receiving a new liver can be "fast-tracked" to return to a surgical ward room following their transplant, bypassing a one- or two-day stay in the Intensive Care Unit. In the September issue of the American Journal of Transplantation, the physicians and researchers have turned their knowledge of who can be safely fast-tracked into a scoring system that other transplant centers can also use — thus sparing patients potentially overly aggressive treatment and saving substantial healthcare dollars.More

OPTN proposals for public comment, including HOPE Act requirements
The OPTN has published for public comment 18 proposals relating to policies and bylaws. Comments will be accepted through Dec. 5, 2014. Among these is the Proposal to Address the Requirements Outlined in the HIV Organ Policy Equity Act, which amends OPTN policies to allow members to participate in the research study in accordance with upcoming changes to the Final Rule and criteria developed by the Secretary of Health and Human Services (HHS). More

Give the gift of research!
The holiday season will be here soon! As you plan your end of year giving, please consider the ASTS Foundation Fund the Future Campaign. Supporting the ASTS Research Grants is a gift to the entire field of transplantation! More

ASTS history in your hands
The ASTS 40th anniversary book is full of pictures and fun facts about the Society, it's members and the field of transplantation. One free copy is available to ASTS members, and non-members can purchase a copy in the ASTS Store. More

Molecular landscape of T cell-mediated rejection in human kidney transplants: prominence of CTLA4 and PD ligands
American Journal of Transplantation (login required)
We used expression microarrays to characterize the changes most specific for pure T cell–mediated rejection (TCMR) compared to other diseases including antibody-mediated rejection in 703 human kidney transplant biopsies, using a Discovery Set–Validation Set approach. The expression of thousands of transcripts — fold change and association strength—changed in a pattern that was highly conserved between the Discovery and Validation sets, reflecting a hierarchy of T cell signaling, costimulation, antigen-presenting cell (APC) activation and interferon-gamma (IFNG) expression and effects, with weaker associations for inflammasome activation, innate immunity, cytotoxic molecules and parenchymal injury. More

Transplant plus native nephrectomy may benefit polycystic kidney disease patients
Renal & Urology News
Native unilateral nephrectomies in conjunction with renal transplantation in patients with autosomal dominant polycystic kidney disease (ADPKD) can improve control of hypertension, according to study findings presented at the 32nd World Congress of Endourology in Taipei, Taiwan. A team at Indiana University School of Medicine in Indianapolis led by Chandru P. Sundaram, M.D., retrospectively examined hypertension control in 143 ADPKD patients who underwent renal transplantation from 2003 to 2013. More

Organ transplant patients had high clinical outcomes, satisfaction following TJA
Although patients who undergo elective total joint arthroplasty after organ transplantation experienced a relatively higher risk of perioperative medical complications, re-operation and periprosthetic infection, clinical outcome measures and patient-reported satisfaction were very high, according to study results. Researchers retrospectively reviewed charts for all patients who underwent primary total joint arthroplasty following kidney, liver, cardiac or lung transplantation between 1999 and 2012 and identified 76 TJAs in 56 solid organ transplant patients. More

Predictors of quality of life in patients evaluated for liver transplantation
Clinical Transplantation (login required)
Health-related quality of life (HRQOL) is severely impaired in advanced liver disease. The purpose of this study was to evaluate the impact of actual liver function and disease-specific factors on HRQOL of patients evaluated for liver transplantation. More

Predictor of tissue injury in kidney transplant recipients possibly found
Researchers at UC San Francisco and Rush University Medical Center, Chicago, may have found a predictor for a disorder affecting kidney transplant recipients that can accelerate organ failure, a discovery that eventually could allow for customized therapies and improved patient selection for transplant. More

Kidney and liver transplantation in children with fibrocystic liver–kidney disease: Data from the US Scientific Registry of Transplant Recipients: 1990–2010
Pediatric Transplantation (login required)
The natural history and survival of children with fibrocystic liver–kidney disease undergoing solid organ transplantation have infrequently been described. We report outcomes in a cohort of US children with fibrocystic liver–kidney disease receiving solid organ transplants over 20 years. Retrospective cohort study of pediatric transplant recipients with diagnoses of fibrocystic liver–kidney disease from 1/1990 to 3/2010, using data from the SRTR.More

Lungs from donors who die from drowning, asphyxiation may be safe for transplant
Medical News Today
Lungs from individuals whose cause of death is drowning or asphyxiation are usually excluded from routine donation. But a new study claims patients transplanted with lungs from such donors have similar outcomes and survival rates as patients who receive lungs from traditional donors.More

Mortality, transplant rates greater in patients with liver injury from nonbodybuilding supplements
Patients with liver injury attributed to ingesting nonbodybuilding herbal and dietary supplements had greater mortality and liver transplantation rates compared with patients taking bodybuilding supplements, according to new study data. Patients with hepatoxicity were recruited from eight referral centers in the Drug-Induced Liver Injury Network to evaluate liver injury due to herbal and dietary supplements. More