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Kidney retransplantation in the ipsilateral iliac fossa: A surgical challenge
American Journal of Transplantation (login required)
The aim of this study is to review the surgical outcome of kidney retransplantation in the ipsilateral iliac fossa in comparison to first kidney transplants. The database was screened for retransplantations between 1995 and 2013. Each study patient was matched with three patients with a first kidney transplantation. Just for graft and patient survival analyses, we added an extra control group including all patients receiving a second transplantation in the contralateral iliac fossa.
Abstract submission open for ASTS Winter Symposium
As more patients suffer due to the shortage of life-saving donor organs each year, the American Society of Transplant Surgeons is focusing its Winter Symposium on innovative science and effective public policy to combat this crisis. Abstracts must be submitted by Sept. 8, 2015.
Registration open for ASTS Leadership Development Program
Join us Sept. 27-30 at Northwestern University's Kellogg School of Management for this interactive, one-of-a-kind course and gain the essential skills to successfully lead transplant centers within a complex financial and regulatory environment.
QAPI Adverse Events webinar available online
Did you miss last Wednesday's webinar on Adverse Events? You can view the recording online. ASTS, AST, and the CMS Survey and Certification Group are pleased to provide this series on various Quality Assessment and Performance Improvement (QAPI) topics.
Overcoming the body mass index as a barrier in kidney transplantation
American Journal of Transplantation (login required)
Evidence suggests that obesity may contribute to the development of many acute and chronic disease states including chronic kidney disease. However, once these conditions have emerged, being obese appears to counterintuitively provide protective advantages and even survival benefits. Although the biologic plausibility of the so-called "obesity paradox" has remained unclear, the consistency of data is remarkable, leaving little doubt that these associations are beyond statistical discoveries. This is of particular importance in dialysis-dependent CKD patents in whom higher body mass index is unfailingly associated with greater survival including during the time they await kidney transplantation, which may span over half a decade.
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Variation by center and economic burden of readmissions after
Liver Transplantation (login required)
The rate and causes of hospital readmissions after liver transplantation remain largely unknown in the United States. Adult patients undergoing LT from 2007 to 2011 were examined with a linkage of the University HealthSystem Consortium and Scientific Registry of Transplant Recipients databases to determine the incidence and risk factors for 30-day readmissions and utilization metrics 90 days after LT.
Study supports living-donor liver transplants
Gastroenterology & Endoscopy News
Patients who receive a liver transplant from a living donor experience outcomes as good as — if not better than — those of individuals who receive an organ from a deceased donor, researchers have found. The findings mark a shift from studies in the 1990s and early 2000s, when three-year survival rates for live-donor liver grafts were not much above 60 percent. Now they are over 80% and appear to be climbing, according to the researchers, who presented their findings at the 2014 Liver Meeting of the American Association for the Study of Liver Diseases. Experts said the results indicate that live-donor livers can help ease shortage of the organs available for transplant.
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Organ transplant rejection may not be permanent
Rejection of transplanted organs in hosts that were previously tolerant may not be permanent, report scientists from the University of Chicago. Using a mouse model of cardiac transplantation, they found that immune tolerance can spontaneously recover after an infection-triggered rejection event, and that hosts can accept subsequent transplants as soon as a week after. This process depends on regulatory T-cells, a component of the immune system that acts as a "brake" for other immune cells. The findings, published online in Nature Communications on July 7, support inducing immune tolerance as a viable strategy to achieve life-long transplant survival.
The impact of hepatitis E in the liver transplant setting
Journal of Hepatology
Hepatitis E virus infection has been identified as a cause of graft hepatitis in liver transplant recipients. The true frequency and clinical importance of HEV infections after liver transplantations is a matter of debate. It is proposed that consumption of HEV-contaminated undercooked meat is a main source for HEV infections in developed countries — which might also account for some hepatitis E cases after organ transplantation.
Study: Organ donation gap isn't due to racial disparity
By Chelsea Adams
New research in the American Journal of Transplantation shows geographic gaps in organ donation rates are not due to the prevalence of racial or ethnic populations — a common belief among solid organ transplant. Researchers at the University of Pennsylvania and the University of Kansas looked at data from on all "eligible deaths." Eligible deaths are potential brain-dead organ donors age 70 years or less without any medical conditions that would prevent organ donation.
Non-alcoholic fatty liver disease following liver transplantation: A clinical review
Clinical Transplantation (login required)
Nonalcoholic steatohepatitis is rapidly becoming the leading indication for liver transplantation in the United States. While post-transplantation outcomes are similar to other indications for transplant, recent evidence has suggested that reduction of risk factors for post-transplant metabolic syndrome may impose a significant survival benefit in this patient population. Cardiovascular mortality is the leading cause of death following transplantation for NASH.
Tracking system increases hepatitis vaccination rates
Medscape (free login required)
For patients awaiting liver transplantation, rates of hepatitis A and hepatitis B vaccination improved significantly after the implementation of nurse-led an intervention. "We improved from a baseline rate of only 45 percent to 87 percent," reported Shari Perez, DNP-C, from the Mayo Clinic in Scottsdale, Arizona. In fact, patients were nearly 9.5 times more likely to complete the vaccination series after the system was implemented, Perez reported here at the American Association of Nurse Practitioners 2015 National Conference.
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