|This message contains images. If you don't see images, click here to view.|
Advertise in this news brief.
Study outlines risk factors for solid organ cancers after liver transplantation
The Oncology Report
The indication for liver transplant, the selection of immunosuppression therapy and smoking status influence the long-term risk of new solid organ malignancies after liver transplantation, Dr. Sebastian Rademacher reported at the 2014 World Transplant Congress. Multivariate analysis showed that recipients' risk of a new solid organ cancer was elevated for those who had a history of smoking (1.89). Risk was reduced for recipients who received tacrolimus, compared with cyclosporine A (0.56), and for patients who had primary biliary cirrhosis/primary sclerosing cholangitis (0.47) or hepatitis C infection (0.21) as the indication for transplantation.
ASTS Recognition Awards nominations due Sept. 15
Has a faculty member, mentor or peer had a positive influence on your career? Say thank you by nominating them for an ASTS Recognition Award!
UNOS liver public forum
ASTS encourages its members to participate in the discussions surrounding the OPTN/UNOS concept document proposing changes to liver allocation. The OPTN/UNOS Liver and Intestinal Organ Transplantation Committee is sponsoring a forum to discuss this concept document on Sept. 16, 2014. You may participate through a live teleconference.
ASTS history book available
If you weren't able to attend the World Transplant Congress and pick up the book chronicling the past 20 years of ASTS history, you can still get a copy! One free copy is available to ASTS members, and non-members can purchase a copy in the ASTS Store.
Parvovirus associated fulminant hepatic failure and aplastic anemia treated successfully with liver and bone marrow transplantation
American Journal of Transplantation (login required)
Aplastic anemia (AA) has been observed in nearly a third of patients undergoing liver transplantation (LT) for non-A-E fulminant hepatic failure (FHF). Few of these patients have been successfully managed with sequential LT and bone marrow transplantation (BMT). No causative agent has been identified for the FHF or AA in these reported cases.
Toward personalized medicine for kidney transplant recipients
UC San Francisco is the lead institution on a new seven-year, $17 million multicenter study funded by the National Institutes of Health to determine if certain immune system cells and/or a drug now used for treating rheumatoid arthritis can be effective in improving and maintaining the long-term health of kidney transplant recipients. The goal of this study is to reduce or eliminate inflammation in kidney transplants and prevent the associated decline in function, thereby maximizing long-term organ survival.
Risk of metabolic complications in kidney transplantation after conversion to mTOR inhibitor: A systematic review and meta-analysis
American Journal of Transplantation (login required)
Mammalian target of rapamycin (mTOR) inhibitors have been used in transplantation with the hope of minimizing calcineurin inhibitor (CNI)-induced nephrotoxicity. However, mTOR inhibitors are also associated with a range of side effects, including metabolic complications. We aimed to determine the risks of metabolic complications after the conversion from CNI to mTOR inhibitor postkidney transplant. A systematic search in PubMed up to September 2013 identified nine relevant trials (a total of 2323 patients). The primary end points were the relative risks (RRs) of new-onset diabetes after transplant (NODAT) and hypercholesterolemia.
$17 million multi-institutional grant to maximize kidney transplant survival
The University of Alabama at Birmingham is participating in a new seven-year, $17 million multicenter study funded by the National Institutes of Health to determine whether certain immune system cells and/or a drug used for treating rheumatoid arthritis can improve and maintain the long-term health of kidney transplant recipients. The goal of the study is to reduce or eliminate inflammation in kidney transplants and prevent the associated decline in graft function, thereby maximizing long-term organ survival. It will involve two clinical trials in parallel by researchers at four sites around the country.
Missed our previous issues? See which articles your colleagues read most.
Long-term effect of childhood liver transplantation on body cell mass
Malnutrition is common in end-stage liver disease, but a correction after transplantation is expected. Body cell mass (BCM) assessment using total body potassium measurements is considered the gold standard for assessing nutritional status. The aim of this study was to examine the BCM and, therefore, nutritional status of long-term survivors after childhood liver transplantation.
Immunosuppressive effects of erythropoietin on human alloreactive T cells
Journal of the American Society of Nephrology (login required)
Correction of anemia with erythropoietin (EPO) is associated with improved kidney transplant outcomes. Emerging evidence, predominantly from animal models, indicates that these observations may be erythropoiesis-independent and that EPO exhibits immunosuppressive properties. This study examined the effects of EPO on human T-cell alloimmunity by first documenting that CD4+ and CD8+ T cells express EPO receptor (EPO-R) on their surfaces.
British hospital performs world's first revived liver transplant
A British hospital has become the first in the world to use a groundbreaking technique to successfully revive a liver for transplant. Surgeons at Birmingham's Queen Elizabeth Hospital are the first to successfully transplant a liver into a patient using a "warm blood" machine to revive the organ after it was transported in an ice box.
Ambulatory ECMO as a bridge to lung transplant in a previously well pediatric patient with ARDS
Extracorporeal membrane oxygenation (ECMO) is increasingly implemented in patients with end-stage pulmonary disease as a bridge to lung transplant. Several centers have instituted an approach that involves physical rehabilitation and ambulation for patients supported with ECMO. Recent reports describe the successful use of ambulatory ECMO in patients with chronic respiratory illnesses being bridged to lung transplant.
7701 Las Colinas Ridge, Ste. 800, Irving, TX 75063