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Health-related quality of life in kidney donors from the last 5 decades
American Journal of Transplantation
Live donation benefits recipients, but the long-term consequences for donors remain uncertain. Renal and Lung Living Donors Evaluation Study surveyed kidney donors (N = 2455; 61 percent women; mean age 58, aged 24–94; mean time from donation 17 years, range 5–48 years) using the Short Form-36 Health Survey (SF-36). The 95 percent confidence intervals for White and African-American donors included or exceeded SF-36 norms.
Nominations open for ASTS Council
Are you an active ASTS member looking to contribute more to your society? Do you have a colleague or mentor who is actively involved in ASTS and is looking to expand their efforts toward important society activities? The ASTS Nominating Committee is accepting nominations for various positions on the ASTS Council for terms beginning in July 2014. Nominations will be accepted until Dec. 2, 2013.
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ASTS members have access to other members' contact information on ASTS.org. You can search by last name, city, state, country, and organization to locate members near you. Log in and get in touch!
OPTN policy requirements for living donor follow-up data reporting
UNOS will hold a webinar on Nov. 6 at 2 p.m. Eastern to provide an overview of new OPTN policy requirements for living kidney donor follow-up data reporting and strategies that programs may choose to incorporate into their practice to improve donor follow-up.
Alemtuzumab induction with tacrolimus monotherapy in 25 pediatric renal transplant recipients
Pediatric Transplantation (login required)
ALA induction in transplantation has been shown to reduce the need for maintenance immunosuppression. Researchers report the outcome of 25 pediatric renal transplants between 2007 and 2010 using ALA induction followed by tacrolimus maintenance monotherapy. Patient ages were 1–19 yr (mean 14 ± 4.1 year). Time of follow-up was 7–51 months (mean 26 ± 13 months). Tacrolimus monotherapy was maintained in 48 percent of patients, and glucocorticoids were avoided in 80 percent of recipients.
Study: Kidney transplant rejection drugs tied to pregnancy risks
HealthDay News via U.S. News & World Report
Drugs meant to reduce the risk of organ rejection may increase the risk of miscarriage and birth defects when taken by female kidney transplant patients, according to a new study. The drugs — called mycophenolic acid products — reduce the risk of organ rejection by suppressing the immune system. The study included 163 female transplant patients who discontinued mycophenolic acid products prior to conception and 114 who conceived while taking the anti-rejection drugs.
Measuring and explaining racial and ethnic differences in willingness to donate live kidneys in the United States
Reasons for U.S. racial–ethnic minority ESRD patients' reported difficulties identifying live kidney donors are poorly understood. Researchers conducted a national study to develop scales measuring willingness to donate live kidneys among U.S. adults (scores ranged from 0 [not willing] to 10 [extremely willing]), and researchers tested whether racial – ethnic differences exist in willingness to donate. Researchers also examined whether clinical, sociodemographic, and attitudinal factors mediated potential racial – ethnic differences in willingness.
Peripheral blood biomarkers for the characterization of alloimmune reactivity after pediatric liver transplantation
Pediatric Transplantation (login required)
Individualization of immunosuppressive medications is an important objective in transplantation medicine. Reliable biomarkers to distinguish between patients dependent from intensive immunosuppressive therapy and those where therapy can be minimized among pediatric transplant recipients receiving immunosuppressive medications are still not established. We evaluated the potential of cross-sectional quantification of regulatory T cells, lymphocyte subsets, and cytokine concentrations as biomarkers in 60 pediatric liver transplant recipients with AR, CR, or normal graft function and in 11 non-transplanted patients.
Trial: Transplanting the highly sensitized patient
Humoral sensitization to antigens of the human leukocyte antigen and ABO systems remains one of the largest barriers to further expansion in renal transplantation. This barrier translates into prolonged waiting time and a greater likelihood of death. The number of highly sensitized patients on the renal transplant waiting list continues to increase. This review focuses on the options available to these patients and speculates on future directions for incompatible transplantation.
Screening for new-onset diabetes after kidney transplantation: Limitations of fasting glucose and advantages of afternoon glucose and glycated hemoglobin
The sensitivity of fasting plasma glucose in screening for new-onset diabetes after transplantation has been questioned, particularly in the presence of moderate-dose prednisolone, where peak plasma glucose occurs 7-8 hours after administration. Oral glucose tolerance testing has been mooted as an alternative but is inconvenient for patients.
Groundbreaking trachea transplant could become routine
The first person to breathe through a tissue-engineered windpipe is still alive today, raising hopes that the science fiction-style transplant could one day become routine.
The unnamed Colombian mother of two was 30 years old when she signed on to swap her tuberculosis-ravaged trachea for a stem cell-seeded donor organ. Now, five years later, the woman leads a "normal" life. "These results confirm what we -- and many patients -- hoped at the time of the original operation: that tissue-engineered transplants are safe and effective in the long term," Dr. Paolo Macchiarini, the Stockholm-based surgeon who pioneered the procedure, said in a statement.
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