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Gene test may spot which kidney transplants more likely to fail
A preliminary gene test may help identify kidney transplant patients at risk of organ rejection, researchers report. Organ rejection occurs in 15 percent to 20 percent of kidney transplant patients, even when they are given drugs to suppress their immune system. Typically, an increase in serum creatinine — a sign of kidney function — warns of impending kidney rejection. A kidney biopsy is then performed to confirm whether a new kidney is being rejected by the body, according to background information in the study.
ASTS Research Grants open
Submissions for the 2015 ASTS Research Grants are being accepted until Jan. 9, 2015, at 3 p.m. Eastern.
Get ready for Giving Tuesday
Giving Tuesday is the day set aside for charitable giving after Black Friday, Small Business Saturday, and Cyber Monday. This year, ASTS is excited to announce that the first $5,000 in donations to the ASTS Foundation will be matched on Dec. 2, Giving Tuesday! Please plan to participate and make your support for the Society count twice.
ASTS history in your hands
The ASTS 40th anniversary book is full of pictures and fun facts about the Society, its members, and the field of transplantation. One free copy is available to ASTS members, and non-members can purchase a copy in the ASTS Store.
A complete treatment of adult living donor liver transplantation: A review of surgical technique and current challenges to expand indication of patients
American Journal of Transplantation (login required)
The growing disparity between the number of liver transplant candidates and the supply of deceased donor organs has motivated the development of living donor liver transplantation (LDLT). Over the last two decades, the operation has been markedly improved by innovations rendering modern results comparable with those of deceased donor liver transplantation (DDLT). However, there remains room for further innovation, particularly in adult living donor liver transplantation (ALDLT).
Preop factors affect CVD risk after liver transplant
Medscape (login required)
A look at nearly 33,000 liver transplant recipients suggests that modifiable pretransplant risk factors can account for major adverse cardiovascular events in the first 3 months after surgery.
"What was most interesting to us was that the thromboembolic diseases, which we tend to screen for very closely — pulmonary embolism, myocardial infarction — only accounted for about 7 percent to 10 percent of all cases of cardiovascular complications," Lisa VanWagner, M.D., from the Northwestern University Feinberg School of Medicine in Chicago.
Actual and perceived knowledge of kidney transplantation and the pursuit of a live donor
Transplantation (login required)
Live donor kidney transplantation (LDKT) remains underutilized, partly resulting from the challenges many patients face in asking someone to donate. Actual and perceived kidney transplantation (KT) knowledge are potentially modifiable factors that may influence this process. Therefore, we sought to explore the relationships between these constructs and the pursuit of LDKT.
Missed our previous issues? See which articles your colleagues read most.
Antifungal prophylaxis in liver transplantation: A systematic review and network meta-analysis
American Journal of Transplantation
Invasive fungal infections cause significant morbidity and mortality in liver transplant recipients, but the need and best agent for prophylaxis is uncertain. A comprehensive literature search was performed to identify randomized controlled trials comparing regimens for antifungal prophylaxis in liver transplant recipients. Direct comparisons were made between treatments using random-effects meta-analysis and a Bayesian network meta-analysis was performed for the primary end point of proven IFI.
Reframing the impact of combined heart-liver allocation on liver transplant wait-list candidates
Liver Transplantation (login required)
Simultaneous heart-liver (H-L) transplantation, although rare, has become more common in the United States. When the primary organ is a heart or liver, patients receiving an offer for the primary organ automatically receive the second, nonprimary organ from that donor. This policy raises issues of equity, such as whether liver transplantation alone candidates bypassed by H-L recipients are disadvantaged. No prior published analyses have addressed this issue, and few methods have been developed as means of measuring the impact of such allocation policies.
Survival after transplant for HCV decreased at long-term follow-up
Data from a single-center study of patients who underwent liver transplantation for hepatitis C virus demonstrate a decreased rate of survival between 10 and 20 years. The study included 789 patients with HCV who underwent transplantation at the University of Pittsburgh from 1993 to 2013.
The overall survival rate was 52 percent at 10 years, 42.4 percent at 15 years and 32.9 percent at 20 years.
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