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Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function
American Journal of Transplantation    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Significant deficiencies in understanding of xenospecific immunity have impeded the success of preclinical trials in xenoislet transplantation. Although galactose-α1,3-galactose, the gal epitope, has emerged as the principal target of rejection in pig-to-primate models of solid organ transplant, the importance of gal-specific immunity in islet xenotransplant models has yet to be clearly demonstrated. Here, we directly compare the immunogenicity, survival and function of neonatal porcine islets from gal-expressing wild-type or gal-deficient galactosyl transferase knockout donors. More


Draft PHS guidelines: ASTS submits comments; individual comments deadline extended to Friday, Dec. 23
ASTS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
ASTS continues to express strong opposition to the draft PHS Guidelines for Reducing the Transmission of HIV, HBV and HCV through Solid Organ Transplantation through its comments to the CDC. We are concerned that these guidelines, as currently drafted, are too restrictive and, if finalized as proposed, will increase organ wastage and many transplant patients will be unnecessarily deprived of life-saving transplants. ASTS has partnered with AST, AOPO and NATCO to implore HHS to stop the implementation of the draft guidelines as currently written and instead initiate a new process to develop meaningful guidelines reflective of the evidence and consensus expert opinion. Additionally, we continue to remind HHS of the need for greater interagency coordination of policies related to transplantation. We remain hopeful that our collaborative efforts will make an impact and that the transplant community will have a voice in the final guidelines. You still have time to influence this process by submitting individual comments by Friday, Dec. 23, 2011.

Lace up! Inaugural ASTS 5K Fun Run/Walk
ASTS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Dust off your running shoes and plan to participate in the Inaugural ASTS 5K Fun Run/Walk which will take place Sunday, Jan. 15, 2012. This event is in conjunction with the ASTS 12th Annual State of the Art Winter Symposium, Jan. 12-15, 2012 at the Loews Miami Beach Hotel. What better way to demonstrate support of patient health and increased quality of life for transplant patients, than by promoting physical fitness? Rain or shine, check-in and warm-up begins at 6:15 a.m. and the race kicks off at 6:30 a.m. just outside the hotel. Awards will be given to the top three male runners and walkers and the top three female runners and walkers of all age levels! Astellas Pharma, USA, Inc. is a proud Sponsor of this event. Register today, and see the sunrise as you run or walk along the Miami shores.


Making sure kidney donors stay healthy long after the transplant
The Huffington Post    Share    Share on FacebookTwitterShare on LinkedinE-mail article
More and more people are donating one of their kidneys to a loved one, a friend, even a stranger, and now a move is on to make sure those donors really fare as well as they're promised. Specialists insist the surgery rarely brings serious complications for the donor. What's less certain is the risk of any long-term health consequences, in part because transplant centers can lose track of donors after they go home. More

Patient decision making about organ quality in liver transplantation
Liver Transplantation via Transplant Now (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
It is challenging to discuss the use of high-risk organs with patients, in part because of the lack of information about how patients view this topic. This study was designed to determine how patients think about organ quality and to test formats for risk communication. More

Posttransplant lymphoproliferative disorders: A continued threat for kidney transplant recipients
American Journal of Kidney Diseases    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Lymphoid neoplasia continues to pose a serious problem for immunosuppressed recipients of solid organ transplants. Previous studies, derived mostly from analyses of registry data, suggest that posttransplant lymphoma occurs in 1 percent to 2 percent of kidney transplant recipients, translating to a risk that is 10- to 20-fold higher than that in the general population. Over 90 percent of cases of posttransplant lymphoma have been linked to proliferation of Epstein-Barr virus (EBV)-infected B cells resulting from suppression of normal immune surveillance by immunosuppressive therapy. More

Strategies toward single-donor islets of Langerhans transplantation
Current Opinion in Organ Transplantation    Share    Share on FacebookTwitterShare on LinkedinE-mail article
If single-donor islet transplantation can be achieved routinely, therapy will become more widely available, more accepted by the transplant community (currently pancreas transplantation requires only a single donor), and this situation will have a major impact overall as an effective treatment option in T1DM. More

Surgical drugs shortage might undermine patient safety
Medical News Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
According to a special article in the December issue of Anesthesia & Analgesia, the official journal of the International Anesthesia Research Society, the United States is facing ongoing shortages of several critical anesthesia medications, which could have a potentially serious impact on patient care and safety. More

What is the goal with endogenous filtration markers — estimation of GFR or prediction of kidney outcomes?
American Journal of Kidney Diseases    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A narrative common to nephrology is the following: "Glomerular filtration rate (GFR) is the best overall marker of kidney function. Therefore, optimizing the estimation of GFR from endogenous filtration markers will improve the diagnosis and management of patients with chronic kidney disease." In the American Journal of Kidney Diseases, NA Bhavsar and colleagues present data from the African American Study of Kidney Disease and Hypertension that challenge this narrative. More

Transplant outcomes unaffected by high-dose erythropoietin
Renal & Urology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
High-dose erythropoietin has no significant effect on short- or long-term graft function in renal transplant patients who had chronic kidney disease after receiving a deceased donor organ, according to a new study. More

More nonalcoholic steatohepatitis requiring transplant
Medscape News (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Nonalcoholic steatohepatitis (NASH) as an indication for liver transplantation rose five-fold from 2002 to 2009. Although metabolic changes related to NASH risk have increased in the general population as a whole, the criteria for establishing risk for NASH-related liver failure remain unclear, according to data presented at The Liver Meeting 2011: American Association for the Study of Liver Diseases 62nd Annual Meeting. More

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Colby Horton, Vice President of Publishing, 469.420.2601
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