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February 14, 2019
News From Medscape
The following recommended articles on are freely available through the partnership between ABC and Medscape, no registration or login required.
Statin Benefits in the Elderly: New Meta-Analysis
Statins reduce vascular events in all age groups, including people older than 75 years, according to the results of a new meta-analysis from the Cholesterol Treatment Trialists' Collaboration.
PFO Closure After Stroke Shows Long-term Benefits
For patients who underwent closure of a patent foramen ovale after having experienced a cryptogenic stroke or transient ischemic attack, the rate of long-term recurrent stroke was low. New findings reinforce the benefits of this procedure.
Feb 1, 2019 This Week in Cardiology Podcast
Check out the latest stories from the cardiology news world that John Mandrola, MD commented on in his weekly podcast.
Should All Medical Schools Have Free Tuition?
Bioethicist Art Caplan discusses this issue with Robert Grossman, dean and CEO of NYU Langone Medical Center, and Tim Rice, deputy director of Health Policy at the Manhattan Institute.
Items of Interest
Sanofi and Regeneron Offer Praluent (Alirocumab) at a New Reduced U.S. List Price
Beginning in early March 2019, new U.S. National Drug Code options will be available at approximately 60% less than the original price. Out-of-pocket costs for Medicare patients could be lowered to approximately $25 to $150 per month.
Comment from Chair of ABC's Access to Care Initiative on Alirocumab's Reduced Price

"Especially for our high risk patients, clinicians strive to offer the best evidence-based care possible, regardless of race/ethnicity, geography or socioeconomic status. Recent data have shown that alirocumab reduces the total nonfatal cardiovascular events and deaths compared to placebo and high-intensity or maximum-tolerated statin therapy, after acute coronary syndrome. Our society must make newer, advanced therapies, such as PCSK9 inhibitors, available to all appropriate patients. If drug developers and healthcare payors remove barriers related to access and cost, it will be a huge advance in offering all our patients optimal cardiovascular care."

- Keith C. Ferdinand, MD FACC ,FAHA,FASH,FNLA
Chair, ABC Access Initiative
Gerald S. Berenson Endowed Chair in Preventive Cardiology,
Professor, Tulane University SOM
HHS Proposes New Regulation to Lower Drug Costs by Targeting Backdoor Rebates and Encouraging Direct Discounts to Patients
This proposal has the potential to be the most sweeping change to how Americans’ drugs are priced at the pharmacy counter, ever, by delivering discounts directly to patients at the pharmacy counter and bringing much-needed transparency to a broken system.
Featured Articles by Members
ABC Members: We welcome your published research submissions and articles for inclusion in future issues of Clinical Updates and Insights. Email Rachel Williams at and please attach file or include links to the original published work and/or abstract.
Adherence to Guideline-Directed Stroke Prevention Therapy for Atrial Fibrillation is Achievable: First Results from Get With The Guidelines-Atrial Fibrillation
Co-authored by Gregg C. Fonarow (Jonathan P. Piccini, Haolin Xu, Margueritte Cox, Roland A. Matsouaka, Javed Butler, Anne B. Curtis, Nihar Desai, Margaret Fang, Pamela J. McCabe, Robert L. Page, Mintu Turakhia, Andrea M. Russo, Bradley P. Knight, Mandeep Sidhu, Jodie L. Hurwitz, Kenneth A. Ellenbogen, and William R. Lewis)
Among hospitals participating in the GWTG-AFIB quality improvement program, OAC prescription at discharge in eligible guideline-indicated patients increased significantly and improved consistently over time.
Promoting Diversity in the Clinical and Translational Research Workforce
Co-authored by Dr. Elizabeth Ofili M.D., M.P.H. and Dr. Priscilla Pemu M.D., M.S.C.R. (with Dr. Estela S. Estape M.T., Ph.D.; Dr. Alexander Quarshie M.D., M.S.; Dr. Barbara Segarra M.T., D.HSc; Prof. María San Martin M.T., M.S.; Dr. Ruth Ríos Ph.D.; Dr. Karen Martínez M.D., M.Sc.; Ms. Jacquelyn Ali M.S.A.; and Ms. Ulochi Nwagwu M.P.H.)
The positive impact of diversity in increasing the effectiveness of the research workforce has been undeniably demonstrated to be an essential element for achieving health equity.
Race/Ethnicity-Specific Associations between Smoking, Serum Leptin, and Abdominal Fat: The Multi-Ethnic Study of Atherosclerosis
Co-authored by Carlos J. Rodriguez (with Sina Kianoush, Andrew P. DeFilippis, Mahmoud Al Rifai, Emelia J. Benjamin, Michael E. Hall, Pamela Ouyang, Matthew A. Allison, Michael J. Blaha)
Multivariable linear regression models were used to assess the race/ethnicity-specific associations between smoking, serum loge-leptin levels, and computed tomography ascertained abdominal fat.
Featured Articles From the Archives
In honor of Black History Month we are featuring published work –– research, case studies or editorial comments –– by some of ABC's founding and early members.
Lack of Accentuation by the Valsalva Maneuver of the Murmur of Idiopathic Hypertrophic Subaortic Stenosis: Importance of Monitoring the Pulse
Co-authored by ABC Founding Member Alphonzo Jordan, MD (with Thierry H. Lejemtel, MD, Hillel S. Ribner, MD, Joel A. Strom, MD and Edmund H. Sonnenblick, MD)
A patient was studied who clearly demonstrated the importance of considering variations in the peripheral pulse when assessing the response to the Valsalva maneuver in individuals with suspected hypertrophic subaortic stenosis.
Centrally Acting Alpha-2 Agonists, Peripherally Acting Adrenergic-Blocking Drugs, and Direct Vasodilators in the Treatment of Mild and Moderate Essential Hypertension
Co-authored by ABC Early Member and Past President Jay Brown M.D., F.A.C.C. (with G. Branche M.D.; M. Streets R.N.; A. King M.D.; V. Dowdy R.N.; J. Batts R.N.)
The centrally acting adrenoceptor agonists, the peripherally acting adrenoceptor blocking agents, and direct vasodilators are effective antihypertensive drugs when employed as double or triple drug therapy in the treatment of mild to moderate hypertension.
Upcoming Events

March 16 - 18

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Friday, March 15, 4:00 pm – 5:00 pm
ACC Diversity and Inclusion Town Hall
Reception honoring Dr. Richard Allen Williams will immediately follow
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ABC Fellows Annual Educational Program and Dr. Jay Brown Best Abstract Competition
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Saturday. March 16, 6:00 pm – 8:30 pm
ABC General Membership Dinner Meeting
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Sunday, March 17, 7:30 am – 8:45 am
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A collaboration with ABC, the University of Maryland, and the Patient-Centered Outcomes Research Institute.
Eldrin F. Lewis, MD, MPH

New Orleans Marriott
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Sunday, March 17, 10:45 am – 12:15 pm
ABC-ACC Joint Symposium
“New Paradigms in Contemporary Cardiovascular Care: Application of Guideline-Directed Therapies – Implications for Minority Populations and Resolution of Disparities”
John M. Fontaine, MD, MBA
Henry Okafor, MD

New Orleans Ernest N. Morial Convention Center
900 Convention Center Blvd, New Orleans, LA 70130

Omni Shoreham Hotel | Washington, DC

CRT 2019 Featured Session
Disparities: Inequalities in Interventional Cardiology
March 3, 2019 | 7:00pm - 9:30pm

Clinical Trials Research:
Upping Your Game

Professional Development for Women Cardiologists Seeking to Succeed in Clinical Research

Applications Due February 28

Heart House | Washington, DC
May 6-7, 2019

2019 Heart Rhythm Scientific Sessions

May 8 - 11

W San Francisco
181 3rd Street

Deadline To Book: February 21
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