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April 11, 2019
News From Medscape
The following recommended articles on are freely available through the partnership between ABC and Medscape, no registration or login required.
Renal Denervation: Blood Pressure Benefit in New Meta-analysis
A new meta-analysis of six sham-controlled studies of renal sympathetic denervation (RSD) has shown a significant reduction in blood pressure with the technique.
Genetic Validation for New LDL Cholesterol-Lowering Target
A new study confirms the mechanism by which ATP citrate lyase inhibition lowers plasma low-density-lipoprotein cholesterol (LDL-C) levels and provides genetic validation for this as a target for cardiovascular risk reduction.
Taking the Pulse of the Apple Heart Study
The Apple Heart Study (AHS) showed that it's possible to enroll almost 420,000 people in a study in less than a year. That is remarkable and surely related to the virtual nature of the enrollment. We should not discount the novelty and importance of this. When we look back at history, AHS may stand out as the beginning of a new way of doing research.
A Physician Investor Tells: Smartest Financial Steps for Young Doctors
Financial experts cite three key principles that can help young physicians start building their net worth. Those important concepts involve: (1) deciding how much to save regularly; (2) taking advantage of compound interest; and (3) investing your money wisely.
Items of Interest
Superhero Movies: A Perspective From a Woman in Medicine
Sherry-Ann Brown, MD
History and the current civic climate might suggest that it is impossible for women and men to be fully and equally respected in society. However, the response of the public to the #MeToo and #TimesUp movements may suggest otherwise. Recent blockbuster superhero movies would support the notion that indeed the impossible might be possible.
She Created a "For Us, By Us" Healthcare Platform for People of Color
Currently, in the United States, African-Americans and Latinos experience 30 to 40% poorer health outcomes than their white counterparts. That’s according to research on Hued, a healthcare technology platform that was created by entrepreneur Kimberly Wilson.
Featured Articles by Members
ABC Members: We welcome your published research submissions and articles for inclusion in future issues of Clinical Updates and Insights. Email Rachel Williams at and please attach file or include links to the original published work and/or abstract.
Exercise Promotes a Cardioprotective Gene Program in Resident Cardiac Fibroblasts
Co-authored by Jeffrey D. Alexis (with Janet K. Lighthouse, Ryan M. Burke, Lissette S. Velasquez, Ronald A. Dirkx Jr., Alessandro Aiezza II, Christine S. Moravec, Alex Rosenberg, and Eric M. Small)
Exercise and heart disease both induce cardiac remodeling, but only disease causes fibrosis and compromises heart function. The cardioprotective benefits of exercise have been attributed to changes in cardiomyocyte physiology, but the impact of exercise on cardiac fibroblasts (CFs) is unknown. Here, RNA-sequencing reveals rapid divergence of CF transcriptional programs during exercise and disease.
Risk Factors Associated With Significant Bleeding Events After Ultrasound-Guided Percutaneous Native Renal Biopsies
Co-authored by Eddie Greene (with Hannah Monahan, Tina Gunderson, Grant Schmit, Thomas Atwell, John Schmitz)
This study aimed to review the incidence of significant bleeding complications after ultrasound-guided percutaneous core native renal biopsies at a single center using a standardized technique.
The Breast Radiologist as a Public Educator: Designing an Effective Presentation for a Lay Audience
Co-authored by Annette I. Joe, MD (with Marilyn A. Roubidoux, MD, Deborah O. Jeffries, MD, Stephanie K. Patterson, MD and Janet E. Bailey, MD)
Educating the public about breast cancer screening and diagnosis is important. Medical and regulatory agencies encourage shared decision making about undergoing breast cancer screening, and there are many places women can get information and misinformation.
Upcoming Events
MQ 2019 Featured Session
Blueprint for Change:
Defining and Promoting a Single, Effective System
of Care for Patients with High Blood Pressure

Friday, April 12 | 1:00pm - 5:00pm
ACCOuNT Pilot Grant Application
The African American Pharmacogenomic Consortium Network Transdisciplinary Collaborative Center (ACCOuNT TCC) – a partnership between ITM investigators and Northwestern University – is offering a Pilot Grant Program to stimulate community stakeholders to be the principal drivers of pharmacogenomics-enabling research projects that they conceive, plan, and execute with support from research collaborators.
Two projects focused on African American cardiovascular pharmacogenomics, or how a person’s genes impact their reaction to drugs for the heart and blood vessels, will be awarded each year. Awards will be made for up to $25,000 for each project. The applications must be submitted by April 26, 2019 at 5:00pm.

In addition to community-based organizations and clinician investigators, the organization is encouraging voluntary health organizations and public health departments to apply for funding. For more information please visit the link below.

Summer Training For Underrepresented Junior Facilty
Washington University in St. Louis School of Medicine offers an all-expense paid summer institute program, initiated and funded by the NHLBI, to increase diversity in the field of Cardiovascular Disease Comorbidities, Genetics and Epidemiology.
Program Includes:
Two consecutive summers with two-week all-expense paid
summer institute, Mid-Year & Annual Meeting to:

  • Establish partnerships between Mentors and Mentees based on mutualresearch interests

  • Participate in training via lectures and workshops on various topics relatedto Cardiovascular Disease Comorbidities, Genetics, and Epidemiology

  • Participate in special grant-writing sessions conducted by NHLBI scientificprogram staff and PRIDE faculty

  • Compete for Small Research Project (SRP) funding for generatingpreliminary data for subsequent NHLBI grant applications

  • Develop the skills needed to apply for research grants and promoting asustainable independent research program for career development
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