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May 9, 2019
News From Medscape
The following recommended articles on are freely available through the partnership between ABC and Medscape, no registration or login required.
3D Printer Makes Swaths of Cardiac Tissue and a Tiny 'Heart'
Imagine a 3D printer using "bioinks" made of human cells and extracellular-matrix material to assemble, layer upon layer, flat swaths of tissue laced with vessels that could potentially serve as patches for damaged myocardium.
CVD Risk Similar in Men, Women With Diabetes, but Care Differs
The increased risk of cardiovascular disease (CVD) upon developing type 2 diabetes is similar in men and women, show data from a large UK-based study of newly diagnosed patients. The new findings contradict prior studies and are the first to show that the proportionate CVD risk increase upon developing type 2 diabetes is similar between the sexes.
Should Docs Tout Products and Personal Causes Online?
More and more today, because of social media, doctors are sharing personal opinions on all sorts of topics, from politics, to healthcare reform, to endorsing certain ideas about healthcare, all the way to the personal hygiene products they might like or use. What should we make of this trend?
Washington University Med School Latest to Offer Free Tuition
The Washington University School of Medicine in St. Louis on Wednesday became the seventh US medical school to offer its students free tuition, as the national trend starts to build momentum, according to a school news release.
Items of Interest
U.S. Heart Failure Rates Are Rising, Especially for Black Adults
After years of decline and despite treatment advances, the risk of dying early from heart failure-related causes started increasing after 2012, new research shows. Black men seem especially hard hit by this troubling new trend, the study authors noted.
Importance of Physician Well Being in Today's Practice Environment
By Renee Bullock-Palmer, MD
Each year in the United States, we lose talented physician colleagues to suicide and we are left asking ourselves how could this have been avoided. Over the last few years there has been an increasing focus on physician well being and avoiding physician burnout within the medical community. This endeavor in raising awareness within the medical community has extended to national medical meetings with focused sessions on physician well being.
Compendium on the Pathophysiology and Treatment of Hypertension
Antihypertensive treatment will be addressed by this second Compendium, which is devoted to the challenges of reducing BP, mainly through lifestyle changes and BP-lowering drugs, whenever BP elevations are detected by appropriate measurements.
FDA Approves New Treatments for Heart Disease Caused by a Serious Rare Disease, Transthyretin Mediated Amyloidosis
On May 3, the U.S. Food and Drug Administration approved Vyndaqel (tafamidis meglumine) and Vyndamax (tafamidis) capsules for the treatment of the heart disease (cardiomyopathy) caused by transthyretin mediated amyloidosis (ATTR-CM) in adults. These are the first FDA-approved treatments for ATTR-CM. Vyndaqel and Vyndamax have the same active moiety, tafamidis, but they are not substitutable on a milligram to milligram basis and their recommended doses differ.
ABC Announces New and Re-Appointed Leaders to Its Board of Directors
Featured Articles by Members
ABC Members: We welcome your published research submissions and articles for inclusion in future issues of Clinical Updates and Insights. Email Rachel Williams at and please attach file or include links to the original published work and/or abstract.
Is Electrocardiography-Left Ventricular Hypertrophy an Obsolete Marker for Determining Heart Failure Risk With Hypertension?
Co-authored by Keith C. Ferdinand (and Carola Maraboto)
Hypertension is a major risk factor for heart failure (HF), preceding it in 75% of patients, and present in 60% to 89% of people with HF with preserved ejection fraction, perhaps representing the main causative factor. Left ventricular hypertrophy (LVH), an increase in left ventricular mass (LVM), is an adaptive response proven to be a strong marker of cardiovascular disease (CVD) morbidity, including HF, and mortality.
Masked Hypertension: Whom and How to Screen?
Co-authored by lead author D. Edmund Anstey and Marwah Abdalla (with Nathalie Moise and Ian Kronish)
Masked hypertension is an important clinical phenotype to detect. Future research is needed in order to develop optimal screening strategies, and to understand population level implications of using ambulatory or home blood pressure monitoring on blood pressure control.
Race and Sex Differences in Asleep Blood Pressure: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Co-authored by D. Edmund Anstey MD, MPH (with John N. Booth III PhD, Natalie A. Bello MD, MPH, Byron C. Jaeger PhD, Daniel N. Pugliese MD, Stephen Justin Thomas PhD, Luqin Deng PhD, James M. Shikany DrPH, Donald Lloyd-Jones MD, ScM, et al.)
Nocturnal hypertension and non‐dipping blood pressure are each associated with increased risk of cardiovascular disease. The study determined differences in nocturnal hypertension and non‐dipping systolic/diastolic blood pressure among black and white men and women who underwent 24‐hour ambulatory blood pressure monitoring at the Coronary Artery Risk Development in Young Adults study Year 30 Exam in 2015‐2016.
Relation of Admission Blood Pressure to In-hospital and 90-Day Outcomes in Patients Presenting With Transient Ischemic Attack
Co-authored by Gregg C. Fonarow, MD (with Sripal Bangalore, MD, MHA, Lee H. Schwamm, MD, Eric E. Smith, MD, MPH, Anne S. Hellkamp, MS, Ying Xian, MD, PhD, Phillip J. Schulte, Ph.D, Jeffrey L. Saver, MD, Deepak L. Bhatt, MD, MPH)
The association between admission blood pressure (BP) and outcomes in patients with transient ischemic attack (TIA) is not well defined. Patients in the United States national Get With The Guidelines-Stroke registry with a TIA were included. Admission systolic and diastolic BP was used to compute mean arterial pressure and pulse pressure (PP).
Community Outreach to African-Americans: Implementations for Controlling Hypertension
By Samar Nasser and Keith C. Ferdinand
The purpose of this review is to examine the impact and effectiveness of community interventions for controlling hypertension in African-Americans. The questions addressed are as follows: Which salient prior and current community efforts focus on African-Americans and are most effective in controlling hypertension and patient-related outcomes? How are these efforts implemented and possibly sustained?

Clinical Trial News
New Long-Term TEGSEDI Safety and Efficacy Data Featured as an Oral Presentation at 2019 American Academy of Neurology Annual Meeting (AAN)
Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy: A Clinical Trial
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
National Stroke Awareness Month
National High Blood Pressure Education Month
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