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June 20, 2019
News From Medscape
The following recommended articles on Medscape.com are freely available through the partnership between ABC and Medscape, no registration or login required.
CAROLINA Reassures on CV Safety for Linagliptin, Glimepiride in Type 2 Diabetes
There are no major differences in cardiovascular outcomes between the dipeptidyl peptidase 4 (DPP-4) inhibitor linagliptin (Tradjenta, Boehringer Ingelheim/Lilly) and the sulfonylurea glimepiride (Amaryl, Sanofi) among patients with early type 2 diabetes at increased cardiovascular risk, new research indicates.
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AI Not Quite Ready to Make the Call on Stroke Imaging
Despite the much-heralded promise of artificial intelligence (AI) to help neurologists and radiologists interpret CT and MR perfusion scans in people suspected of stroke, the automated approach still falls short of pinpointing a diagnosis compared with human expertise.
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CDC Data Show Cancer, Heart Disease Mortality Trending Down
The Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS) has released current quarterly data of provisional mortality rates for several top causes of death in the United States. The data show cancer and heart disease trended downward in the last quarter of 2018.
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Ordering Advanced Imaging? Get Ready for New Medicare Rules
Starting in January 2020, Medicare will require that providers use a certified clinical decision support (CDS) system when ordering advanced imaging tests for eight common conditions. Physicians should start preparing for the changes now, according to the authors of an article published online earlier this month.
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Items of Interest
Preventive Cardio-Oncology: The Role Of High Intensity Interval Training
By Sherry-Ann Brown, MD, PhD
Heart disease is the number one killer of survivors of cancer. It is our responsibility to help our patients with cancer understand and mitigate this risk. Prevention of heart disease in these patients should occur at three stages: in Cardio-Oncology prehabilitation, habilitation, and rehabilitation.
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Is synthetic apelin the insulin of heart disease?
Canadian researchers have singled out a peptide known as apelin that could improve survival in CV patients with aortic aneurysms, leading them to dub the molecule the equivalent of insulin for heart disease. Gavin Oudit, a professor of cardiology at the University of Alberta, is part of the team that first tested apelin in mice—a $400,000 project that simulated human-like aortic aneurysms in the rodents and tested the efficacy of apelin on their survival.
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Chemo-Induced Heart Failure Responds to CRT
Cardiac resynchronization therapy (CRT) improved heart function and outcomes for patients with chemotherapy-induced cardiomyopathy, the MADIT-CHIC study showed. Left ventricular ejection fraction (EF) improved a relative 38% over 6 months after implantation, reported Jagmeet Singh, MD, DPhil, of Massachusetts General Hospital in Boston.
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AHA News: Study Provides Rare Look at Stroke Risk, Survival Among American Indians
Race matters when it comes to who is more likely to have a stroke and to die from one. For American Indians, just how much it matters has been unclear due to a lack of research. But results of a new study indicate they are more likely than white Americans to have a stroke but less likely than black Americans. And for those who do have a stroke, American Indians are more likely to die within a month compared to both white and black stroke patients.
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Million-Person U.S. Study of Genes and Health Stumbles Over Including Native American Groups
Earlier this month, leaders of the National Institutes of Health (NIH) in Bethesda, Maryland, celebrated the 1-year anniversary of the effort, called All of Us, which aims to gather DNA and health records for 1 million volunteers by the end of 2024. They pointed with pride to the study's diversity: More than 50% of the 143,000 volunteers fully enrolled so far belong to minority groups. They did not mention that Native Americans, who make up 1.7% of the U.S. population, are not formally on board.
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Lack of diversity in genomic research hinders precision medicine for nonwhite Americans
A new study uncovers 65 genetic variants found in understudied minority populations that could lead to improved precision medicine for those groups and highlights the need for equitable inclusion of diverse populations in genetic research.
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Featured Articles by Members
ABC Members: We welcome your published research submissions and articles for inclusion in future issues of Clinical Updates and Insights. Email Rachel Williams at rwilliams@abcardio.org and please attach file or include links to the original published work and/or abstract.
Black Immigrants from Africa and the Caribbean Have Similar Rates of Diabetes but Africans Are Less Obese: The New York City Community Health Survey 2009-2013
Co-authored by Anne E. Sumner (with Margrethe F. Horlyck-Romanovsky, Melissa Fuster, Sandra E. Echeverria, Katarzyna Wyka, May May Leung, and Terry T.-K. Huang)
This study was designed to determine (a) whether the prevalence and odds of either obesity or diabetes differed in foreign-born black Africans and Caribbeans living in New York City (NYC) and (b) whether time in the United States (US) affected odds of either outcome.
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EDITORIAL COMMENT: The Tale of a Double-Edged Sword: Protecting the Heart from Metastatic Melanoma Tumor and its Treatment with Pembrolizumab
By Giselle A. Suero-Abreu and Sherry-Ann Brown
In this Inaugural issue of JACC: Case Reports, Dr. Suero-Abreu and Brown discuss Larsen et al. case report on "Remission of a Perimyocardial Melanoma Metastasis With Pembrolizumab Treatment." This editorial acknowledges the remarkable benefit but also potential cardiotoxicity seen with novel cancer agents such as checkpoint inhibitors, and highlights the importance of the crucial field of cardio-oncology.
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Allostatic Load: Importance, Markers, and Score Determination in Minority and Disparity Populations
Co-authored by Anne E. Sumner (with Erik J. Rodriquez, Edward N. Kim, Anna M. Nápoles and Eliseo J. Pérez-Stable)
Allostatic load is a physiological measure of the cumulative burden of stress on the body assessed by markers of physiological dysregulation. It is a multisystem construct that quantifies biological risk which leads to poor health and maladaptive trajectories. In this overview they build upon previous reviews by discussing four key aspects of allostatic load.
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Association Between Sleep Apnea and Blood Pressure Control Among Blacks: Jackson Heart Sleep Study
Co-authored by Marwah Abdalla (with Dayna A. Johnson, S. Justin Thomas, Na Guo, Yuichiro Yano, Michael Rueschman, Rikki M. Tanner, Murray A. Mittleman, David A. Calhoun, James G. Wilson, Paul Muntner and Susan Redline)
Blacks have a high prevalence of hypertension and uncontrolled blood pressure (BP), each of which may be partially explained by untreated sleep apnea. They investigated the association of sleep apnea with uncontrolled BP and resistant hypertension in blacks.
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Giving a keynote speech? Presenting at a Grand Round? Receiving an Award? Interviewed by the Press? Published in a journal? Presenter or Panelist at a Conference? Graduating? Please Share. We LOVE to LEARN how our ABC Members are making a difference! Email Rachel Williams at rwilliams@abcardio.org or please tag or DM us on Facebook, Twitter or Instagram with links/details, so we can spotlight your #excellence in our newsletter!

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