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June 27, 2019
News From Medscape
The following recommended articles on are freely available through the partnership between ABC and Medscape, no registration or login required.
New AHA/HFSA Statement on Diabetes and Heart Failure
The American Heart Association (AHA) and the Heart Failure Society of America (HFSA) have issued a new scientific statement on the management of comorbid type 2 diabetes mellitus (DM) and heart failure (HF).
PIONEER 6: Will Oral Semaglutide Live Up to Promise in Real World?
An investigational oral version of the GLP-1 agonist semaglutide (Novo Nordisk) is safe in patients with type 2 diabetes at high cardiovascular (CV) risk, with a nonsignificant 21% reduction in major adverse cardiac events (MACE), the results of PIONEER 6 show.
Medscape Cardiologist Wealth and Debt Report 2019
Today's financial picture for physicians shows both highs and lows. Some doctors are stockpiling savings while others are struggling to pay off debt and live a comfortable lifestyle.
Items of Interest
Clinical Research Pathways [Guest Post] Diversity in Clinical Trials: Preparing Physicians to Make a Difference
By Priscilla Pemu, MD, MS
The U.S. has become increasingly diverse, yet that diversity is not reflected in the clinical trials that play a key role in which new medicines are approved and, ultimately, prescribed to the general public. Because of this underrepresentation, much of what we know about new medicines—including their effectiveness and potential side effects—might not apply to nearly one-third of Americans.
Millennials less heart-healthy than Gen Xers at the same age
Millennials in their mid-thirties are less healthy than Generation Xers were at the same age, a recent analysis by Blue Cross Blue Shield found—a gap driven largely by poorer mental, cardiovascular and endocrine health outcomes in the younger generation.
Study: Health worsening among less-educated adults over last 20 years
Despite expanded healthcare coverage for the vulnerable, health disparities for less-educated Americans still exist, according to a new study from the Robert Wood Johnson Foundation (RWJF). All less-educated adults—across racial, ethnic and geographical lines—have seen worsening health between 1997 and 2017, especially within the increases in obesity.
VIDEO: Diabetes, CVD, and Guideline Evolution: Recent trials prompt paradigm shift in treatment
Diabetes has long been seen as a condition of abnormal glucose metabolism, despite also being associated with cardiovascular disease. But recent results from the EMPA-REG OUTCOME, SUSTAIN-6, LEADER, and CANVAS trials are shifting that focus. In this video, Javed Butler, MD, PhD, of Stony Brook University School of Medicine in New York, explains how these changing views are affecting guidelines on disease management.
Featured Articles by Members
ABC Members: We welcome your published research submissions and articles for inclusion in future issues of Clinical Updates and Insights. Email Rachel Williams at and please attach file or include links to the original published work and/or abstract.
Human Induced Pluripotent Stem Cell Derived Cardiomyocyte Patch in Rats with Heart Failure
Co-authored by Ikeotunye R. Chinyere, BS (with Jordan J. Lancaster, PhD, Pablo Sanchez, MD, Giuliana Repetti, BS, Elizabeth Juneman, MD, Amitabh Pandey, MD, Talal Moukabary, MD, Nicole LaHood, MD, Sherry Daugherty, BS, Steven Goldman, MD)
To treat chronic heart failure (CHF), we developed a robust, easy to handle bio absorbable tissue-engineered patch embedded with human neonatal fibroblasts and human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs). This patch was implanted on the epicardial surface of the heart covering the previously infarcted tissue.
Neighborhood social cohesion is associated with lower levels of interleukin-6 in African American women
Co-authored by Priscilla E. Pemu, Gary H. Gibbons and Tené T. Lewis (with Vanessa L. Neergheen, Matthew Topel, Miriam E. Van Dyke, Samaah Sullivan, Viola Vaccarino and Arshed A. Quyyumi)
Prior research has also established that race and gender can modify the effects of neighborhood features, including social cohesion, on CVD risk factors and outcomes. This study aimed to examine the association between social cohesion and the inflammatory biomarkers interleukin-6 (IL-6) and C-reactive protein (CRP) in a cohort of African American and White women and men.

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