Under the Microscope
Jan. 22, 2014

Histology Leader Webinars are coming up fast!
Join NSH in their new webinar series designed for educators, supervisors, managers and those that are in a leadership role in histology. The series begins at 1 p.m. EST Feb. 5 with Linda McDonald, HT (ASCP), from Cleveland Clinic who will be discussing "What Competency Really Is." This webinar is a basic overview of competency, including definitions of terminology, examples of school/educational and job related competencies. View more webinar topics and register by clicking here.More

Quality control of mitochondria could be defense against disease
EMBO via Bioscience Technology
Scientists from the Montreal Neurological Institute and Hospital in Canada have discovered that two genes linked to hereditary Parkinson's disease are involved in the early-stage quality control of mitochondria. The protective mechanism, which is reported in The EMBO Journal, removes damaged proteins that arise from oxidative stress from mitochondria. More

Gene therapy leads to robust improvements in animal model
of fatal muscle disease

University of Washington
Preclinical studies show that gene therapy can improve muscle strength in small- and large-animal models of a fatal congenital childhood disease know as X-linked myotubular myopathy. The findings, appearing in the Jan. 22 issue of Science Translational Medicine, also demonstrate the feasibility of future clinical trials of gene therapy for this devastating disease.More

Brain development: Researchers identify key protein
Scientists from the Max F. Perutz Laboratories of the University of Vienna and the Medical University of Vienna have identified a specific enzyme, histone deacetylase 2, as essential for brain development. The findings published in Development are important to advance the development of new drugs to treat neurological diseases. A group of proteins, the histone deacetylases, have been on the watch list of scientists worldwide for more than two decades. This attention is owed to their important function in epigenetics: histone deacetylases coordinate the transcription of genetic information and play an important role in the development of diseases such as cancer and neurodegenerative disorders.More

Genome of intestinal disease bacteria to be sequenced
University of Liverpool via Bioscience Technology
The University of Liverpool is set to decipher the genomes of the U.K.'s main bacterial cause of food poisoning which results in more than 21,000 hospital admissions and 100 deaths each year. Using the latest whole genome sequencing technologies available at the University's Centre for Genomic Research, scientists will decode and analyze the 510 archived isolates of Campylobacter from earlier collections of human feces.More

Fever treatments may cause more flu deaths
People sick with the flu often take medication to alleviate the accompanying fever. But their relief may come at a price for others: New findings suggest that suppressing fever can result in the infection of tens of thousands of additional people each flu season. Fever, though unpleasant, can actually be beneficial. The condition can lower the amounts of virus in a sick person's body, because viruses replicate less efficiently in higher temperatures. Fever can also help immune responses work better.More

Preventing cell death from infection
R&D Magazine
Scientists at The Scripps Research Institute have demonstrated the power of a new drug discovery technique, which allows them to find — relatively quickly and cheaply — antibodies that have a desired effect on cells. The TSRI scientists used the technique to discover two antibodies that protect human cells from a cold virus. The finding includes the useful insight that the cold virus can be stopped by targeting a key viral enzyme in just the right way. More

Doctors' clothing can spread infectious disease
VideoBrief Those white coats doctors wear to keep a professional appearance could actually make you sick. Studies have shown doctors' clothing can spread infectious diseases to patients. So, Healthcare Epidemiology of America is suggesting new guidelines. They say doctors should wear short sleeves and no watches, jewelry or ties when seeing patients.More

Data mining Google may help predict disease outbreaks
Psych Central
Emerging research suggests mining Google queries could give public health officials a heads-up on emerging infectious disease outbreaks. In a new study published in Lancet Infectious Diseases, Internet-based surveillance has been found to detect infectious diseases such dengue fever and influenza up to two weeks earlier than traditional surveillance methods.More