Under the Microscope
Jul. 1, 2015

Brightfield RNA in situ hybridization with RNAScope is one of the presentations featured at the July 18 Forum on Immunohistochemistry
In situ hybridization is used by researchers to examine gene expression in the context of pathologic changes in tissues. This technique detects nucleic acids that are preserved in a tissue specimen by using hybridization probes that are complementary to the nucleic acid target and visualized with either fluorescent (FISH) or chromogenic (CISH) dyes. The general principles and technological advances for RNA ISH will be reviewed. Join us in Tennessee for the eighth annual IHC Forum where the application of the RNAScope method for FFPE tissues in research studies is discussed to demonstrate the capabilities of this more sensitive and specific technique for bright-field analyses of cytoplasmic mRNAs with several practical examples provided. This improved methodology relies on multiple targeted probes that are used to increase specific binding to genes of interest and for serial amplification of a signal. Learn more.More

Join in July 9 to learn 'Why Do My Medications Cost So Much?'
This individual NSH webinar will highlight the behind the scenes process in developing a drug for medical use. Join in at 1 p.m. EST, Thursday, July 9, to obtain tips on how you can save money on your prescription drugs plus things you can do to choose wellness over sickness. Learn more.More

July 22 laboratory webinar — How to Integrate HistoQIP into a Quality Management Program
Quality assurance involves continuous monitoring of technical and medical procedures and is an essential part of a well-developed quality management program. The Histology Quality Improvement Program (HistoQIP) allows the user to monitor the quality of technical work performed and compare the quality to recognized standards and peers. In addition, HistoQIP provides referenced solutions to common problems allowing for quality improvement changes for identified quality variances. Register now.More

Scanadu preparing consumer self-test device for review by FDA as part of its mission to enable patients to monitor their health without need for clinical pathology lab tests
Dark Daily
Now gathering study data needed to launch a review by the Food and Drug Administration is a low-cost lab urinalysis device that returns results via a smartphone for conditions such as pregnancy and diabetes. More significant for pathologists and clinical laboratory executives, this handy point-of-care device is capable of doing tests for traditional medical laboratory tests, ranging from glucose and leukocytes to bilirubin and creatinine. More

University installs most powerful microscope in the US
Lab Manager
Rice University, renowned for nanoscale science, has installed microscopes that will allow researchers to peer deeper than ever into the fabric of the universe. The Titan Themis scanning/transmission electron microscope, one of the most powerful in the United States, will enable scientists from Rice as well as academic and industrial partners to view and analyze materials smaller than a nanometer — a billionth of a meter — with startling clarity.More

New stem cell research uncovers causes of spinal muscular atrophy
Royal Holloway, University of London via Medical Xpress
New research from the Advanced Gene and Cell Therapy Lab at Royal Holloway, University of London has used pioneering stem cell techniques to better understand why certain cells are more at risk of degenerating in spinal muscular atrophy than others. Spinal muscular atrophy is a devastating hereditary disease and is the biggest genetic killer in infancy.More

Better cell culture through metabolomics
Genetic Engineering & Biotechnology News
Relationships between metabolic events and productivity in Chinese hamster ovary cells have become better established over the past several years. Through metabolomics, scientists have uncovered strategies for the design of culture media and feeds leading to longer-lived, highly productive cultures. Many platform processes for monoclonal antibodies were developed in this manner.More

Team identifies gene responsible for some cases of male infertility
University of Pennsylvania via Medical Xpress
In the most severe form of male infertility, men do not make any measurable levels of sperm. This condition, called azoospermia, affects approximately 1 percent of the male population and is responsible for about a sixth of cases of male infertility. Oftentimes men with azoospermia don't know the underlying cause of their condition. But new research led by University of Pennsylvania scientists suggests that mutations in an X chromosome gene called TEX11 are responsible for a significant number of cases of infertility — an estimated 1 percent of cases of non-obstructive azoospermia.More

The marketing advantages of clinical trials
Natural Products Insider
Successful companies are able to demonstrate that their products are safe and effective. One of the best ways to achieve this is by testing the efficacy of a dietary supplement, over-the-counter drug or homeopathic product in human subjects. When the benefits of a company's product are shown to be statistically significant in a randomized double-blind, placebo-controlled study, both consumers and the company are assured that the product meets its label claims. Companies that want to strengthen sales of a particular product should invest in a clinical trial performed by a third-party contract research organization in human volunteers to achieve this end. More

Finding genomes with 'knockout' genes leads to development of new therapeutic drugs, along with clinical lab tests for these biomarkers
Dark Daily
Pharmaceutical companies and other research programs are developing a new opportunity to use information from human genome sequencing to create a new class of therapeutic drugs. These drugs target "knockout genes" and those same genes are expected to be used as diagnostic biomarkers for clinical laboratory testing as a new field of companion diagnostics emerges. More

Candidate MERS vaccine set for human clinical trials to protect people against coronavirus infection
A study published in the Journal of Virology had proposed a potential vaccine that can protect people against harmful infection of coronavirus — the virus that causes Middle East Respiratory Syndrome. At present, no protective vaccine has been available in medical centers against the coronavirus strain responsible for MERS. With the wide-spread of the disease in some parts of the world, there is a need for such a vaccine that would resolve the sudden outbreak which had already cost many lives since its onset.More